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dc.contributor.authorTorof, Elham
dc.contributor.authorMorrissey, Hana
dc.contributor.authorBall, Patrick
dc.date.accessioned2023-02-23T09:20:06Z
dc.date.available2023-02-23T09:20:06Z
dc.date.issued2023-02-21
dc.identifier.citationTorof E, Morrissey H, Ball PA (2023) The Role of Antibiotic Use in Third Molar Tooth Extractions: A Systematic Review and Meta-Analysis. Medicina, 59(3):422. https://doi.org/10.3390/medicina59030422en
dc.identifier.issn1010-660Xen
dc.identifier.doi10.3390/medicina59030422en
dc.identifier.urihttp://hdl.handle.net/2436/625120
dc.description© 2023 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/medicina59030422en
dc.description.abstractBackground and Objectives: Anecdotal evidence suggested variation in practices for antibiotic prescribing around dental procedures including route of administration of antibiotics, timing of the course prescribed (before, after or both), length of course prescribed, narrow vs. broad spectrum agents prescribed, use of single or combination of antibiotics, and the use of loading doses. This review aims to investigate this disparity of practices and the absence of global and local recent consensus on the most appropriate antibiotic interventions around invasive dental procedures. Material and methods: Following PRISMA-P© methodology, a systematic review of randomised controlled clinical trials was designed, reviewed, and entered on the PROSPERO© website prior to commencement. Ethics approval was gained from the University of Wolverhampton Committee. Searches were performed using PubMed©, Science Direct™, and the Cochrane Database, plus the bibliographies of studies identified. They investigated studies examining the efficacy and safety of any antibiotic regimen tested, independent of regimen used, versus a placebo, control, or no therapy, on outcomes in post third molar extraction. Results: The primary outcome of interest was postoperative infection and secondary outcomes were other post-surgical related complications of infectious nature and antibiotic adverse events. Sixteen RCTs were identified that met the selection criteria. Antibiotic use was reported to be safe, causing few adverse events. Meta-analysis of infection events showed antibiotics reduced the risk of an infection by 69%, but routine use for prophylaxis in uncomplicated procedures was not supported, and their role in patients with comorbidities or impaired immunity remains controversial. The effect on the incidence of dry socket showed no difference based upon regimen used. No significant benefit was found with respect to reduction of intraoral inflammation, wound dehiscence, haematoma, and lymphadenopathy. Conclusion: The effect on postoperative pain reduction was inconclusive. Routine use of antibiotics around M3 extraction procedures is not supported, but their use in the presence of co-morbidities and or immunosuppression remains controversial to be confirmed by future studies.en
dc.formatapplication/pdfen
dc.languageEnglish
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urlhttps://www.mdpi.com/1648-9144/59/3/422en
dc.subjectantibiotic prophylaxisen
dc.subjectdental extractionen
dc.subjectdental infectionen
dc.titleThe role of antibiotic use in third molar tooth extractions: A systematic review and meta-analysisen
dc.typeJournal articleen
dc.identifier.eissn1648-9144
dc.identifier.journalMedicinaen
dc.date.updated2023-02-22T09:16:00Z
dc.identifier.articlenumber422
dc.date.accepted2023-02-17
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW23022023HMen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2023-02-23en
dc.source.volume2023, 59(3), 422
dc.source.volume59
dc.source.issue3
dc.source.beginpage1
refterms.dateFCD2023-02-23T09:19:42Z
refterms.versionFCDVoR
refterms.dateFOA2023-02-23T09:20:07Z


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