Wolverhampton Intellectual Repository and E-Theses
WIRE is the open access repository for research publications and outputs by researchers based at the University of Wolverhampton.
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Recent Submissions
Item From heritage BIM towards an ‘echo-based’ modelling approach: developing a new paradigm for the digital creation of lost architectural heritage(University of Wolverhampton, 2025)The recreation of lost and partially lost heritage buildings presents a major challenge in the field of digital heritage. While Heritage Building Information Modelling (HBIM) has advanced significantly in the documentation of existing heritage, its application to buildings that no longer physically exist remains limited. These cases often lack measurable or visual records, requiring novel methods to construct credible and authentic digital representations based on intangible data. This study aims to extend the HBIM paradigm by developing a new modelling approach for the authentic recreation of lost architectural heritage using oral histories and AI techniques. The research introduces an Echo-Based Modelling Approach, which translates first-hand descriptive memories into structured architectural terminology, suitable for generating visual models. A five-phase methodological framework was developed and tested. Phase 1 engineered a Standardised Heritage Prompt Template (SHePT); Phase 2 introduced Heritage Questions (HQs) for eliciting descriptive input; Phase 3 developed the Architectural Heritage Transformer (AHT), an ontology-based tool for mapping plain language responses to architectural terms; Phase 4 involved the automation of data handling; and Phase 5 integrated AI text-to-image generation tools to recreate visual representations of lost buildings. The framework was evaluated through a case study of a building in the West Midlands, UK. The findings demonstrate that the approach can effectively convert intangible memory-based data into usable architectural input, offering a new pathway for HBIM applications where no physical or visual record exists. This study contributes to the theoretical expansion of HBIM to encompass intangible heritage sources and proposes a practical toolset that may influence future research, conservation practice, and policy related to lost heritage reconstruction.Item Establishing the priorities for dementia care curricula in higher education: the views of carers of people living with dementia and Admiral Nurses(University of Wolverhampton, 2025)The study focused on understanding the perspective of carers of people living with dementia and Admiral Nurses. The aim being to produce a broader insight into understanding dementia care education priorities in the higher education curricula for student nurses. To achieve this the study focused on four research objectives, these were: 1. To obtain the views of carers of people living with dementia regarding the key dementia education priorities for student nurses. 2. To obtain the views of Admiral Nurses regarding the key dementia education priorities for student nurses. 3. To determine if there are key differences in terms of the education priorities between the two groups. 4. To establish how their views inform the dementia education priorities in the pre-registration nursing curricula. The research has incorporated a pragmatic approach. To maintain congruence and philosophical alignment, this study used a qualitative e-Delphi method of data collection to solicit the views of the expert groups and reach consensus. The expert views obtained in this study emphasised the diverse ways that dementia can impact the person living with the condition and their family. When comparing the views of carers to the views of Admiral Nurses key differences were established. Admiral Nurses identified 34 topic areas, whereas the carers identified 12. The study provided further evidence regarding the complexity of dementia education and demonstrated the breadth of knowledge needed to deliver dementia care. Nine key recommendations have been put forward, these include: the need for direct reference to dementia to be included within the platforms of the standards of proficiency for registered nurses (Nursing and Midwifery Council (NMC), 2024a). Student nurses’ need an understanding of dementia. Education on the brain and the changes that occur because of dementia, including an understanding of memory is recommended. Emphasis was placed on the importance of person-centred care and family centred care; this was seen as being essential. Alongside this it was felt that focus needs to be placed on seeing the positive aspects of what the person living with dementia is still able to do rather than what they have lost. Student nurses need to develop knowledge and skills in communication and dementia. Managing distress reactions and pain, using non-pharmacological approaches was highlighted as important. Student nurses require educational content relating to the progressive nature of dementia. Student nurses need to be aware of the impact of dementia on the carer and be able to support them by having an awareness of the services available in their local area.Item PLGA-nano-encapsulated disulfiram inhibits cancer stem cells and targets non-small cell lung cancer in vitro and in vivo(MDPI, 2024-12-23)Cancer stem cells (CSCs) play a key role in non-small cell lung cancer (NSCLC) chemoresistance and metastasis. In this study, we used two NSCLC cell lines to investigate the regulating effect of hypoxia in the induction and maintenance of CSC traits. Our study demonstrated hypoxia-induced stemness and chemoresistance at levels comparable to those in typical CSC sphere culture. Activation of the NF-κB pathway (by transfection of NF-κB-p65) plays a key role in NSCLC CSCs and chemoresistance. Disulfiram (DS), an anti-alcoholism drug, showed a strong in vitro anti-CSC effect. It blocked cancer cell sphere reformation and clonogenicity, synergistically enhanced the cytotoxicity of four anti-NSCLC drugs (doxorubicin, gemcitabine, oxaliplatin and paclitaxel) and reversed hypoxia-induced resistance. The effect of DS on CSCs is copper-dependent. A very short half-life in the bloodstream is the major limitation for the translation of DS into a cancer treatment. Our team previously developed a poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated DS (DS-PLGA) with a long half-life in the bloodstream. Intra venous injection of DS-PLGA in combination with the oral application of copper gluconate has strong anticancer efficacy in a metastatic NSCLC mouse model. Further study may be able to translate DS-PLGA into cancer applications.Item Prolactin monitoring for patients on antipsychotic drugs: A narrative review of clinical relevance(Scientific Scholar on behalf of Archives of Biological Psychiatry, 2025-08-09)Hyperprolactinemia is known to be a common side effect of antipsychotic drugs. It is associated with specific symptoms and long-term complications. There are inconsistencies in the monitoring of prolactin in patients taking antipsychotic medications. It was intended to review the recent literature regarding causes, symptoms of hyperprolactinemia, monitoring guidelines about antipsychotic drug-induced hyperprolactinemia, and suggested treatment approaches. There are multiple etiologies of hyperprolactinemia, which include side effects of a wide range of medications. While it is not recommended to monitor prolactin in all patients taking antipsychotic medication routinely, there are variations of approaches based on the antipsychotic drugs and the presence of hyperprolactinemia symptoms. Observations in this narrative review based on current evidence suggest careful clinical investigation and monitoring of hyperprolactinemia in psychiatric patients.
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