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Spectral analysis of body movement during deep brain stimulation in Parkinson’s disease
Patel, Mitesh Nilsson, Maria H Rehncrona, Stig Tjernström, Fredrik Magnusson, Måns Johansson, Rolf Fransson, Per-Anders
Patel, Mitesh
Nilsson, Maria H
Rehncrona, Stig
Tjernström, Fredrik
Magnusson, Måns
Johansson, Rolf
Fransson, Per-Anders
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Other contributors
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Epub Date
Issue Date
2021-03-18
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Abstract
Background
The characteristics of Parkinson’s disease (PD) include postural instability and resting tremor. However, reductions of tremor amplitude do not always improve postural stability.
Research question
What is the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on spectral analysis of body movement in patients with PD when tested without anti-PD medication? The effect of visual cues was also studied.
Methods
Ten patients with PD (mean age 64.3 years, range 59−69 years) and 17 control participants (mean age 71.2 years, range 65–79 years) were recruited. Spectral power following a period of quiet stance (35 s) was analysed in three different spectral power bands (0−4 Hz, 4−7 Hz and 7−25 Hz). Motion markers were secured to the head, shoulder, hip, and knee, which recorded movements in two directions, the anteroposterior and lateral.
Results
DBS STN significantly changed the spectral distribution pattern across the body in the anteroposterior (p = 0.029) and lateral directions (p ≤ 0.003). DBS predominantly reduced spectral power at the head (p ≤ 0.037) and shoulder (p ≤ 0.031) in the lateral direction. The spectral power of the lower and upper body in patients with PD, with DBS ON, were more similar to the control group, than to DBS OFF. Visual cues mainly reduced spectral power in the anteroposterior direction at the shoulder (p ≤ 0.041) in controls and in patients with PD with DBS ON.
Significance
There is an altered postural strategy in patients with PD with DBS ON as shown by an altered spectral power distribution pattern across body segments and a reduction of spectral power in the lateral direction at the head and shoulder. A reduction of spectral power in controls and in patients with PD with DBS ON suggests that visual cues are able to reduce spectral power to some extent, but not with DBS OFF where postural sway and power are larger.
Citation
Patel, M., Nilsson, M.H., Rehncrona, S. et al. (2021) Spectral analysis of body movement during deep brain stimulation in Parkinson’s disease. Gait & Posture, 86, 217-225.
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Journal article
Language
en
Description
This is an accepted manuscript of an article published by Elsevier in Gait and Posture, available online: https://doi.org/10.1016/j.gaitpost.2021.03.023
The accepted version of the publication may differ from the final published version.
Series/Report no.
ISSN
0966-6362