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AbstractExcessive gut luminal iron contributes to the initiation and progression of colorectal cancer. However, emerging evidence suggests that reduced iron intake and low systemic iron levels are also associated with the pathogenesis of colorectal cancer. This is important because patients with colorectal cancer often present with iron deficiency. Iron is necessary for appropriate immunological functions; hence, iron deficiency may hinder cancer immunosurveillance and potentially modify the tumor immune microenvironment, both of which may assist cancer development. This is supported by studies showing that patients with colorectal cancer with iron deficiency have inferior outcomes and reduced response to therapy. Here, we provide an overview of the immunological consequences of iron deficiency and suggest ensuring adequate iron therapy to limit these outcomes.
CitationPhipps, O., Brookes, M.J. and Al-Hassi, H.O. (2021) Iron deficiency, immunology and colorectal cancer, Nutrition Reviews, 79(1), pp. 88–97.
PublisherOxford University Press
DescriptionThis is an accepted manuscript of an article published by OUP in Nutrition Reviews on 17/7/2020, available online at: https://doi.org/10.1093/nutrit/nuaa040 The accepted version of the publication may differ from the final published version.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/