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    Comparison between G6PD-Deficient and Normal Individuals after Eccentric Exercise

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    Authors
    Theodorou, Anastasios A.
    Nikolaidis, Michalis G.
    Paschalis, Vassilis
    Sakellariou, Georgios K.
    Fatouros, Ioannis G.
    Koutedakis, Yiannis
    Jamurtas, Athanasios Z.
    Issue Date
    2010
    
    Metadata
    Show full item record
    Abstract
    Purpose: Theoretically, glucose-6-phosphate dehydrogenase (G6PD)-deficient compared with nondeficient individuals may be less capable of performing physical activities and/or may be more vulnerable to muscle damage and oxidative stress. Therefore, the purpose of the present study was to examine the effects of a resistance muscle-damaging exercise bout on muscle function and damage, redox status in plasma, and erythrocytes and hemolysis. Methods: Nine males with established G6PD deficiency and nine males with normal G6PD activity performed an eccentric muscledamaging exercise protocol. Isometric torque, range of motion, delayed onset muscle soreness, and creatine kinase were measured as indices of muscle function and damage. Reduced glutathione, oxidized glutathione, thiobarbituric acid–reactive substances, protein carbonyls, catalase, uric acid, and total antioxidant capacity were measured as indices of blood redox status. Plasma hemoglobin and bilirubin were measured as indices of hemolysis. All measurements conducted before, immediately after, and 1, 2, 3, 4, and 5 d after exercise. Results: All indices measured confirmed that eccentric exercise induced severe muscle damage, oxidative stress, and hemolysis, peaking at 2 and 3 d postexercise. Lower resting levels of reduced glutathione were detected in the G6PD-deficient group compared with the control group. Nevertheless, both the time course and the magnitude of the changes of the selected muscle performance, redox status (both in plasma and in erythrocytes), and hemolysis indices measured were similar between the two groups. Conclusions: The present study indicates that G6PD-deficient individuals may participate in high-intensity muscle-damaging activities, without a negative impact on muscle function, blood redox status, and hemolysis
    Citation
    Medicine & Science in Sports & Exercise, 42(6) ; 1113-1121
    Publisher
    American College of Sports Medicine
    Journal
    Medicine & Science in Sports & Exercise
    URI
    http://hdl.handle.net/2436/113472
    DOI
    10.1249/MSS.0b013e3181c67ecd
    Additional Links
    http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00005768-900000000-99360
    Type
    Journal article
    Language
    en
    ISSN
    0195-9131
    ae974a485f413a2113503eed53cd6c53
    10.1249/MSS.0b013e3181c67ecd
    Scopus Count
    Collections
    Faculty of Education, Health and Wellbeing

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