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    Psyllium: a promising polymer for sustained release formulations in combination with HPMC polymers.

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    Authors
    Kaialy, Waseem
    Emami, Parastou
    Asare-Addo, Kofi
    Shojaee, Saeed
    Nokhodchi, Ali
    Issue Date
    2014-05-01
    
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    Abstract
    Psyllium has a mucilaginous property that makes it a good candidate to be utilized as an excipient in the preparation of controlled release systems. Various formulations were prepared using theophylline as a model drug and investigated with a view to achieve an ideal slow drug release profile. The addition of hydroxypropyl methylcellulose (HPMC) to psyllium significantly reduced the burst release; however, the percentage of drug release within a 12 h period was too slow and thereby inadequate. This was overcome by the addition of lactose as a hydrophilic filler that enabled a slow release with roughly 80% drug release in 12 h. The inclusion of HPMC within psyllium formulations changed the drug release kinetics from Fickian diffusion to anomalous transport. Granulated formulations demonstrated slower drug release than ungranulated or physical mixture and caused a change in the dissolution kinetics from Fickian diffusion to anomalous transport. Milled granules showed more efficient controlled drug release with no burst release. Milling of the granules also changed the drug release kinetics to anomalous transport. Although psyllium was proved to be a promising polymer to control the drug release, a combination of psyllium-HPMC and formulation processes should be considered in an attempt to achieve a zero-order release.
    Publisher
    Taylor & Francis Online
    Journal
    Pharmaceutical Development and Technology
    URI
    http://hdl.handle.net/2436/621516
    DOI
    10.3109/10837450.2013.775156
    PubMed ID
    23506265
    Type
    Journal article
    Language
    en
    ISSN
    1097-9867
    ae974a485f413a2113503eed53cd6c53
    10.3109/10837450.2013.775156
    Scopus Count
    Collections
    Faculty of Science and Engineering

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