Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility
Authors
Schuh, KaiCartwright, Elizabeth J.
Jankevics, Eriks
Bundschu, Karin
Liebermann, Jürgen
Williams, Judith C.
Armesilla, Angel
Emerson, Michael
Oceandy, Delvac
Knobeloch, Klaus-Peter
Neyses, Ludwig
Issue Date
2004-07-31
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Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility. Furthermore, the PMCA inhibitor 5-(and-6)-carboxyeosin diacetate succinimidyl ester reduced sperm motility in wild-type animals, thus mimicking the effects of PMCA4 deficiency on sperm motility and supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca(2+) levels.Citation
Schuh, K., Cartwright, E.J., Jankevics, E. et al. (2004) Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. Journal of Biological Chemistry, 279(27), pp. 28220-28226.PubMed ID
15078889Additional Links
https://www.jbc.org/article/S0021-9258(20)73260-6/fulltextType
Journal articleLanguage
enISSN
0021-9258ae974a485f413a2113503eed53cd6c53
10.1074/jbc.M312599200
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/