Towards a More Desirable Dry Powder Inhaler Formulation: Large Spray-Dried Mannitol Microspheres Outperform Small Microspheres

2.50
Hdl Handle:
http://hdl.handle.net/2436/621162
Title:
Towards a More Desirable Dry Powder Inhaler Formulation: Large Spray-Dried Mannitol Microspheres Outperform Small Microspheres
Authors:
Kaialy, Waseem; Hussain, Tariq; Alhalaweh, Amjad; Nokhodchi, Ali
Abstract:
Purpose To investigate, for the first time, the performance of a dry powder inhaler (DPI, Aerolizer®) in the case of a model drug (i.e. albuterol sulphate) formulated with spray dried mannitol carrier particles with homogeneous shape and solid–state formbut different sizes. Methods Spray dried mannitol (SDM) particles were characterized in terms of size, surface area, morphology, water content, solid–state, density and electrostatic charge by a novel approach. DPI formulations composed of SDM and albuterol sulphate (AS) were prepared and evaluated in terms of drug content homogeneity and in vitro aerosolization performance. Results All SDM particles generated similar fine particle fractions of AS. Formulations consisting of larger SDM particles demonstrated better drug content homogeneity, reduced amounts of drug loss and reduced oropharyngeal deposition. Comparing different SDM products demonstrated that SDM powders with relatively poorer flowability, wider size distributions and higher charge density generated DPI formulations with poorer drug content homogeneity and deposited higher amount of drug on the inhaler, mouthpiece adaptor and throat. DPI formulation total desirability increased linearly with the mean diameter of SDM. Conclusion Particle shape and solid–state form of mannitol could dominate over carrier size, bulk density, flowability and charge in terms of determining the aerosolization behaviour of AS formulated with mannitol carrier, at least within the experimental protocols applied in the present study.
Citation:
Towards a More Desirable Dry Powder Inhaler Formulation: Large Spray-Dried Mannitol Microspheres Outperform Small Microspheres 2013, 31 (1):60 Pharmaceutical Research
Journal:
Pharmaceutical Research
Issue Date:
6-Aug-2013
URI:
http://hdl.handle.net/2436/621162
DOI:
10.1007/s11095-013-1132-2
Additional Links:
http://link.springer.com/10.1007/s11095-013-1132-2
Type:
Article
Language:
en
ISSN:
0724-8741; 1573-904X
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorHussain, Tariqen
dc.contributor.authorAlhalaweh, Amjaden
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2018-03-09T14:26:40Z-
dc.date.available2018-03-09T14:26:40Z-
dc.date.issued2013-08-06-
dc.identifier.citationTowards a More Desirable Dry Powder Inhaler Formulation: Large Spray-Dried Mannitol Microspheres Outperform Small Microspheres 2013, 31 (1):60 Pharmaceutical Researchen
dc.identifier.issn0724-8741-
dc.identifier.issn1573-904X-
dc.identifier.doi10.1007/s11095-013-1132-2-
dc.identifier.urihttp://hdl.handle.net/2436/621162-
dc.description.abstractPurpose To investigate, for the first time, the performance of a dry powder inhaler (DPI, Aerolizer®) in the case of a model drug (i.e. albuterol sulphate) formulated with spray dried mannitol carrier particles with homogeneous shape and solid–state formbut different sizes. Methods Spray dried mannitol (SDM) particles were characterized in terms of size, surface area, morphology, water content, solid–state, density and electrostatic charge by a novel approach. DPI formulations composed of SDM and albuterol sulphate (AS) were prepared and evaluated in terms of drug content homogeneity and in vitro aerosolization performance. Results All SDM particles generated similar fine particle fractions of AS. Formulations consisting of larger SDM particles demonstrated better drug content homogeneity, reduced amounts of drug loss and reduced oropharyngeal deposition. Comparing different SDM products demonstrated that SDM powders with relatively poorer flowability, wider size distributions and higher charge density generated DPI formulations with poorer drug content homogeneity and deposited higher amount of drug on the inhaler, mouthpiece adaptor and throat. DPI formulation total desirability increased linearly with the mean diameter of SDM. Conclusion Particle shape and solid–state form of mannitol could dominate over carrier size, bulk density, flowability and charge in terms of determining the aerosolization behaviour of AS formulated with mannitol carrier, at least within the experimental protocols applied in the present study.en
dc.language.isoenen
dc.relation.urlhttp://link.springer.com/10.1007/s11095-013-1132-2en
dc.rightsArchived with thanks to Pharmaceutical Researchen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectaerosolizationen
dc.subjectalbuterol sulphateen
dc.subjectelectrostatic chargeen
dc.subjectphysicochemical propertiesen
dc.subjectspray dried mannitolen
dc.titleTowards a More Desirable Dry Powder Inhaler Formulation: Large Spray-Dried Mannitol Microspheres Outperform Small Microspheresen
dc.typeArticleen
dc.identifier.journalPharmaceutical Researchen
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