Gene Loss and Lineage-Specific Restriction-Modification Systems Associated with Niche Differentiation in the Campylobacter jejuni Sequence Type 403 Clonal Complex

2.50
Hdl Handle:
http://hdl.handle.net/2436/621134
Title:
Gene Loss and Lineage-Specific Restriction-Modification Systems Associated with Niche Differentiation in the Campylobacter jejuni Sequence Type 403 Clonal Complex
Authors:
Morley, Laura; McNally, Alan; Paszkiewicz, Konrad; Corander, Jukka; Méric, Guillaume; Sheppard, Samuel K.; Blom, Jochen; Manning, Georgina
Abstract:
ABSTRACT Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry, livestock, and human disease cases to host-adapted specialized lineages primarily associated with livestock or poultry. Here, we present novel data on the ST403 clonal complex of C. jejuni , a lineage that has not been reported in avian hosts. Our data show that the lineage exhibits a distinctive pattern of intralineage recombination that is accompanied by the presence of lineage-specific restriction-modification systems. Furthermore, we show that the ST403 complex has undergone gene decay at a number of loci. Our data provide a putative link between the lack of association with avian hosts of C. jejuni ST403 and both gene gain and gene loss through nonsense mutations in coding sequences of genes, resulting in pseudogene formation.
Citation:
Gene Loss and Lineage-Specific Restriction-Modification Systems Associated with Niche Differentiation in the Campylobacter jejuni Sequence Type 403 Clonal Complex 2015, 81 (11):3641 Applied and Environmental Microbiology
Publisher:
American Society of Microbiology
Journal:
Applied and Environmental Microbiology
Issue Date:
1-Jun-2015
URI:
http://hdl.handle.net/2436/621134
DOI:
10.1128/AEM.00546-15
Additional Links:
http://aem.asm.org/lookup/doi/10.1128/AEM.00546-15
Type:
Article
Language:
en
Description:
My previous place of work was Nottingham Trent University (Georgina Manning)
ISSN:
0099-2240; 1098-5336
Sponsors:
Nottingham Trent University
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorMorley, Lauraen
dc.contributor.authorMcNally, Alanen
dc.contributor.authorPaszkiewicz, Konraden
dc.contributor.authorCorander, Jukkaen
dc.contributor.authorMéric, Guillaumeen
dc.contributor.authorSheppard, Samuel K.en
dc.contributor.authorBlom, Jochenen
dc.contributor.authorManning, Georginaen
dc.date.accessioned2018-02-22T15:49:29Z-
dc.date.available2018-02-22T15:49:29Z-
dc.date.issued2015-06-01-
dc.identifier.citationGene Loss and Lineage-Specific Restriction-Modification Systems Associated with Niche Differentiation in the Campylobacter jejuni Sequence Type 403 Clonal Complex 2015, 81 (11):3641 Applied and Environmental Microbiologyen
dc.identifier.issn0099-2240-
dc.identifier.issn1098-5336-
dc.identifier.doi10.1128/AEM.00546-15-
dc.identifier.urihttp://hdl.handle.net/2436/621134-
dc.descriptionMy previous place of work was Nottingham Trent University (Georgina Manning)en
dc.description.abstractABSTRACT Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry, livestock, and human disease cases to host-adapted specialized lineages primarily associated with livestock or poultry. Here, we present novel data on the ST403 clonal complex of C. jejuni , a lineage that has not been reported in avian hosts. Our data show that the lineage exhibits a distinctive pattern of intralineage recombination that is accompanied by the presence of lineage-specific restriction-modification systems. Furthermore, we show that the ST403 complex has undergone gene decay at a number of loci. Our data provide a putative link between the lack of association with avian hosts of C. jejuni ST403 and both gene gain and gene loss through nonsense mutations in coding sequences of genes, resulting in pseudogene formation.en
dc.description.sponsorshipNottingham Trent Universityen
dc.language.isoenen
dc.publisherAmerican Society of Microbiologyen
dc.relation.urlhttp://aem.asm.org/lookup/doi/10.1128/AEM.00546-15en
dc.rightsArchived with thanks to Applied and Environmental Microbiologyen
dc.subjectCampylobacteren
dc.subjectniche adaptationen
dc.subjectrestriction modification systemsen
dc.subjectgene lossen
dc.subjectST403 clonal complexen
dc.titleGene Loss and Lineage-Specific Restriction-Modification Systems Associated with Niche Differentiation in the Campylobacter jejuni Sequence Type 403 Clonal Complexen
dc.typeArticleen
dc.identifier.journalApplied and Environmental Microbiologyen
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