Comparison Of Relapse Rates Of Depot And Oral Antipsychotics In Patients With Schizophrenia

2.50
Hdl Handle:
http://hdl.handle.net/2436/621122
Title:
Comparison Of Relapse Rates Of Depot And Oral Antipsychotics In Patients With Schizophrenia
Authors:
Mahesh, K H D; Weerasundera,R; Morrissey, Hana; Ball P.A; Subasinghe H.W.A.S
Abstract:
Introduction: Antipsychotics are the mainstay of treatment in schizophrenia. First-generation and second-generation antipsychotics are available as oral and depot formulations. The aim of this study was to compare the relapse rate in patients with schizophrenia treated with depot and oral antipsychotics. Methods: All patients diagnosed with schizophrenia under the Top End Mental Health Service in Darwin, Australia during a period of five years were included. Their medications and history of relapses were retrieved from electronic records. Mean relapses-per-month was calculated and compared using the independent t-test and ANOVA. Results and discussion: The study sample contained 193 patients; 137 were males. The mean relapses-per-month for oral formulations was significantly higher than for depot formulations. Second-generation antipsychotic depot formulations had significantly reduced mean relapses-permonth compared to oral second-generation formulations. The mean relapses-per-month for firstgeneration antipsychotics depot was not significantly different from first-generation depot formulations. First-generation antipsychotics depot formulations were significantly more effective than oral second-generation. Zuclopenthixol appeared to be the best first-generation antipsychotics depot compared to flupenazine and flupenthixol. First-generation antipsychotics depot formulations were equally effective as Second-generation antipsychotics depot formulations. Conclusion: Depot formulations overcome some of the adherence problems with oral therapy, and the resultant continuous therapy is effective in reducing relapse rates.
Publisher:
INTERNATIONAL JOURNAL OF CURRENT MEDICAL AND PHARMACEUTICAL RESEARCH
Journal:
INTERNATIONAL JOURNAL OF CURRENT MEDICAL AND PHARMACEUTICAL RESEARCH
Issue Date:
Jan-2018
URI:
http://hdl.handle.net/2436/621122
Additional Links:
http://journalcmpr.com/archive
Type:
Article
Language:
en
ISSN:
2395-6429
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorMahesh, K H Den
dc.contributor.authorWeerasundera,Ren
dc.contributor.authorMorrissey, Hanaen
dc.contributor.authorBall P.Aen
dc.contributor.authorSubasinghe H.W.A.Sen
dc.date.accessioned2018-02-16T15:32:09Z-
dc.date.available2018-02-16T15:32:09Z-
dc.date.issued2018-01-
dc.identifier.issn2395-6429en
dc.identifier.urihttp://hdl.handle.net/2436/621122-
dc.description.abstractIntroduction: Antipsychotics are the mainstay of treatment in schizophrenia. First-generation and second-generation antipsychotics are available as oral and depot formulations. The aim of this study was to compare the relapse rate in patients with schizophrenia treated with depot and oral antipsychotics. Methods: All patients diagnosed with schizophrenia under the Top End Mental Health Service in Darwin, Australia during a period of five years were included. Their medications and history of relapses were retrieved from electronic records. Mean relapses-per-month was calculated and compared using the independent t-test and ANOVA. Results and discussion: The study sample contained 193 patients; 137 were males. The mean relapses-per-month for oral formulations was significantly higher than for depot formulations. Second-generation antipsychotic depot formulations had significantly reduced mean relapses-permonth compared to oral second-generation formulations. The mean relapses-per-month for firstgeneration antipsychotics depot was not significantly different from first-generation depot formulations. First-generation antipsychotics depot formulations were significantly more effective than oral second-generation. Zuclopenthixol appeared to be the best first-generation antipsychotics depot compared to flupenazine and flupenthixol. First-generation antipsychotics depot formulations were equally effective as Second-generation antipsychotics depot formulations. Conclusion: Depot formulations overcome some of the adherence problems with oral therapy, and the resultant continuous therapy is effective in reducing relapse rates.en
dc.language.isoenen
dc.publisherINTERNATIONAL JOURNAL OF CURRENT MEDICAL AND PHARMACEUTICAL RESEARCHen
dc.relation.urlhttp://journalcmpr.com/archiveen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMean relapses-per-monthen
dc.subjectfirstgeneration antipsychoticsen
dc.subjectSecondgeneration antipsychoticsen
dc.subjectZuclopenthixolen
dc.subjectFlupenazineen
dc.subjectFlupenthixolen
dc.subjectpharmacotherapyen
dc.titleComparison Of Relapse Rates Of Depot And Oral Antipsychotics In Patients With Schizophreniaen
dc.typeArticleen
dc.identifier.journalINTERNATIONAL JOURNAL OF CURRENT MEDICAL AND PHARMACEUTICAL RESEARCHen
dc.date.accepted2017-12-
rioxxterms.funderInternalen
rioxxterms.identifier.projectUoW160218HMen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2018-02-01en
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