In vitro investigation of anti-inflammatory activity and evaluation of phytochemical profile of Syzygium caryophyllatum

4.50
Hdl Handle:
http://hdl.handle.net/2436/621105
Title:
In vitro investigation of anti-inflammatory activity and evaluation of phytochemical profile of Syzygium caryophyllatum
Authors:
Heendeniya, Saumya ( 0000-0002-7685-1675 ) ; Ratnasooriya, W D; Pathirana, R N
Abstract:
This study examined the anti-inflammatory potential of an aquous root extract of Syzygium caryophyllatum (Family: Myrtaceae) and reference drug Declofenac sodium, invitro using heat induced egg albumin denaturation bio assay technique. The concentrations of the root extract used were 781.25, 1562.5, 3125, 6250 and 12500 μg/mL. While diclofenac sodum were 78.12, 156.25, 312.5, 625, 1250 and 2500 μg/mL. Both the extract (r2 = 0.97; P<0.05) and Diclofenac sodium (r2 = 0.87; P<0.05) displayed marked and concentration dependent inhibition of heat-induced protein denaturation with IC50 value of 6.229 *103 μ g/ml and ~1.704*108 μg/mL respectively. Phytochemical analysis of the extract revealed the presence of the flavanoids, phenols, tanins, alkaloids, saponins and amino acids. It is concluded that the aquous root extract of Sri Lankan grown Syzygium caryophyllatum possess marked in vitro antiinflammatory activity which is mediated possibly by flavanoids, tanins and alkaloids. This is a novel finding. Further the results scientifically justify the use of roots of Syzygium caryophyllatum in Sri Lankan traditional medicine to treat inflammation.
Publisher:
Journal of Pharmacognosy and Phytochemistry
Journal:
Journal of Pharmacognosy and Phytochemistry, PAGES: 1759-1763, 2018, VOL. 7, ISSUE 1, PART X
Issue Date:
Jan-2018
URI:
http://hdl.handle.net/2436/621105
Additional Links:
http://www.phytojournal.com/search/?q=In+vitro+investigation+of+anti-inflammatory+activity+and+evaluation+of+phytochemical+profile+of+Syzygium+caryophyllatum
Type:
Article
Language:
en
ISSN:
2278-4136
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorHeendeniya, Saumyaen
dc.contributor.authorRatnasooriya, W Den
dc.contributor.authorPathirana, R Nen
dc.date.accessioned2018-02-15T10:24:20Z-
dc.date.available2018-02-15T10:24:20Z-
dc.date.issued2018-01-
dc.identifier.issn2278-4136en
dc.identifier.urihttp://hdl.handle.net/2436/621105-
dc.description.abstractThis study examined the anti-inflammatory potential of an aquous root extract of Syzygium caryophyllatum (Family: Myrtaceae) and reference drug Declofenac sodium, invitro using heat induced egg albumin denaturation bio assay technique. The concentrations of the root extract used were 781.25, 1562.5, 3125, 6250 and 12500 μg/mL. While diclofenac sodum were 78.12, 156.25, 312.5, 625, 1250 and 2500 μg/mL. Both the extract (r2 = 0.97; P<0.05) and Diclofenac sodium (r2 = 0.87; P<0.05) displayed marked and concentration dependent inhibition of heat-induced protein denaturation with IC50 value of 6.229 *103 μ g/ml and ~1.704*108 μg/mL respectively. Phytochemical analysis of the extract revealed the presence of the flavanoids, phenols, tanins, alkaloids, saponins and amino acids. It is concluded that the aquous root extract of Sri Lankan grown Syzygium caryophyllatum possess marked in vitro antiinflammatory activity which is mediated possibly by flavanoids, tanins and alkaloids. This is a novel finding. Further the results scientifically justify the use of roots of Syzygium caryophyllatum in Sri Lankan traditional medicine to treat inflammation.en
dc.language.isoenen
dc.publisherJournal of Pharmacognosy and Phytochemistryen
dc.relation.urlhttp://www.phytojournal.com/search/?q=In+vitro+investigation+of+anti-inflammatory+activity+and+evaluation+of+phytochemical+profile+of+Syzygium+caryophyllatumen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSyzygium caryophyllatumen
dc.subjectanti-inflammationen
dc.subjectinflammationen
dc.subjectegg albumin denaturation assayen
dc.subjectSri Lankan traditional medicineen
dc.titleIn vitro investigation of anti-inflammatory activity and evaluation of phytochemical profile of Syzygium caryophyllatumen
dc.typeArticleen
dc.identifier.journalJournal of Pharmacognosy and Phytochemistry, PAGES: 1759-1763, 2018, VOL. 7, ISSUE 1, PART Xen
dc.date.accepted2017-12-
rioxxterms.funderInternalen
rioxxterms.identifier.projectUoW150218SNHen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2018-02-15en
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