Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis
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Authors
Fenton, Sally A. M.Sandoo, Aamer
Metsios, George S.
Duda, Joan L.
Kitas, George D.
Veldhuijzen van Zanten, Jet J.C.S.
Issue Date
2018-02-21
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Background: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. Objectives: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. Methods: Sixty-eight RA patients (Mage = 55±12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire). Results: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = − 3.25, p = .02, 95% CI [– 6.07, – .42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN). Conclusion: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.Citation
Fenton, S.A., Sandoo, A., Metsios, G.S., Duda, J.L., Kitas, G.D., & Zanten, J.J. (2018). Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis. Microvascular research, 117 (may 2018), pp 57-60.Publisher
ElsevierJournal
Microvascular ResearchAdditional Links
https://www.sciencedirect.com/science/article/pii/S002628621730242XType
Journal articleLanguage
enISSN
0026-2862ae974a485f413a2113503eed53cd6c53
10.1016/j.mvr.2018.01.005
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