Combination of finite element method and Drucker-Prager Cap material model for simulation of pharmaceutical tableting process

2.50
Hdl Handle:
http://hdl.handle.net/2436/621059
Title:
Combination of finite element method and Drucker-Prager Cap material model for simulation of pharmaceutical tableting process
Authors:
Baroutaji, A. ( 0000-0002-4717-1216 ) ; Lenihan, S.; Bryan, K.
Abstract:
Density-dependent Drucker-Prager Cap (DPC) model is widely used for assessing the compaction behaviour of powders due to its capability of capturing the various phenomena associated with the powder compaction process such as work hardening, nonlinear densification, and frictional and compressible behaviour of the powder. This paper presents a full description of the Drucker-Prager Cap model for the compaction behaviour of microcrystalline cellulose (MCC) Avicel PH101 pharmaceutical powder. The experimental calibration process of Drucker-Prager Cap is detailed and all model parameters are calculated as a function of powder relative density. Also, the calibrated parameters are implemented in finite element code to perform a numerical simulation of a typical pharmaceutical tablet. The results showed that the finite element model (FEM) was able to accurately predict the compaction behaviour of the microcrystalline cellulose powder. Furthermore, the finite element predictions of stress and density distributions of the powders during the compaction were used to analyse the failure mechanisms associated with tableting.
Citation:
Combination of finite element method and Drucker-Prager Cap material model for simulation of pharmaceutical tableting process 2017, 48 (11):1133 Materialwissenschaft und Werkstofftechnik
Publisher:
Wiley
Journal:
Materialwissenschaft und Werkstofftechnik, volume 48 issue 11 on pages 1133 to 1145
Issue Date:
Nov-2017
URI:
http://hdl.handle.net/2436/621059
DOI:
10.1002/mawe.201700048
Additional Links:
http://doi.wiley.com/10.1002/mawe.201700048
Type:
Article
Language:
en
ISSN:
1521-4052
Appears in Collections:
Engineering and Technology

Full metadata record

DC FieldValue Language
dc.contributor.authorBaroutaji, A.en
dc.contributor.authorLenihan, S.en
dc.contributor.authorBryan, K.en
dc.date.accessioned2018-01-31T15:00:23Z-
dc.date.available2018-01-31T15:00:23Z-
dc.date.issued2017-11-
dc.identifier.citationCombination of finite element method and Drucker-Prager Cap material model for simulation of pharmaceutical tableting process 2017, 48 (11):1133 Materialwissenschaft und Werkstofftechniken
dc.identifier.issn1521-4052en
dc.identifier.doi10.1002/mawe.201700048-
dc.identifier.urihttp://hdl.handle.net/2436/621059-
dc.description.abstractDensity-dependent Drucker-Prager Cap (DPC) model is widely used for assessing the compaction behaviour of powders due to its capability of capturing the various phenomena associated with the powder compaction process such as work hardening, nonlinear densification, and frictional and compressible behaviour of the powder. This paper presents a full description of the Drucker-Prager Cap model for the compaction behaviour of microcrystalline cellulose (MCC) Avicel PH101 pharmaceutical powder. The experimental calibration process of Drucker-Prager Cap is detailed and all model parameters are calculated as a function of powder relative density. Also, the calibrated parameters are implemented in finite element code to perform a numerical simulation of a typical pharmaceutical tablet. The results showed that the finite element model (FEM) was able to accurately predict the compaction behaviour of the microcrystalline cellulose powder. Furthermore, the finite element predictions of stress and density distributions of the powders during the compaction were used to analyse the failure mechanisms associated with tableting.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://doi.wiley.com/10.1002/mawe.201700048en
dc.rightsArchived with thanks to Materialwissenschaft und Werkstofftechniken
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTablettingen
dc.subjectPowder compactionen
dc.subjectFinite Element Methoden
dc.subjectDrucker-Prageren
dc.subjectCap modelen
dc.titleCombination of finite element method and Drucker-Prager Cap material model for simulation of pharmaceutical tableting processen
dc.typeArticleen
dc.identifier.journalMaterialwissenschaft und Werkstofftechnik, volume 48 issue 11 on pages 1133 to 1145en
dc.contributor.institutionSchool of Mechanical, Electrical and Process Engineering, Cork Institute of Technology, T12 P928; BISHOPSTOWN, CORK IRELAND-
dc.contributor.institutionSchool of Mechanical, Electrical and Process Engineering, Cork Institute of Technology, T12 P928; BISHOPSTOWN, CORK IRELAND-
dc.contributor.institutionSchool of Mechanical, Electrical and Process Engineering, Cork Institute of Technology, T12 P928; BISHOPSTOWN, CORK IRELAND-
dc.date.accepted2017-11-
rioxxterms.funderPMTCen
rioxxterms.identifier.projectUoW310118ABen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2018-11-01en
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