Welcome to WIRE
(Wolverhampton Intellectual Repository and E-Theses)
WIRE is an open access repository for the research publications and other outputs from postgraduate students and staff at the University of Wolverhampton.
Wolverhampton staff: to deposit your publication to WIRE, go to: https://www.wlv.ac.uk/lib/research/wire/
Use the search box above or the browse function on the left to discover publications from the research community at the University of Wolverhampton.
University students and staff can also search WIRE using LibrarySearch
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What is needed to obtain informed consent and monitor capacity for a successful study involving people with mild dementia? Our experience in a multi-centre studyStrategies on informed consent process and capacity monitoring for mild dementia research are at developing state. We reflected on our experience and found that the successful collection of informed consent and full participation of PwD required the involvement of familiar healthcare professionals/care workers/staff at the recruitment and data collection stages and this needs to occur in an active support environment. Time is another important factor affecting the success of the study.
Targeting Aquaporin-4 subcellular localization to treat central nervous system edema© 2020 The Author(s) Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4 cell-surface abundance increases in response to hypoxia-induced cell swelling in a calmodulin-dependent manner. Calmodulin directly binds the AQP4 carboxyl terminus, causing a specific conformational change and driving AQP4 cell-surface localization. Inhibition of calmodulin in a rat spinal cord injury model with the licensed drug trifluoperazine inhibited AQP4 localization to the blood-spinal cord barrier, ablated CNS edema, and led to accelerated functional recovery compared with untreated animals. We propose that targeting the mechanism of calmodulin-mediated cell-surface localization of AQP4 is a viable strategy for development of CNS edema therapies.
Book review: Austerity and the remaking of European educationWhilst the primary focus of this impressive edited volume is on the ‘long moment of crisis’ arising from the 2008 financial crash and the consequences arising from the decision of national and European Union leaders to respond to it with measures of austerity, Anna Traianou, Ken Jones and their collaborators trace the evolution of education policy making in Europe from the post-war period in which education was a long way from the labour market to its current role across Europe as handmaiden to the market.
Measuring societal impacts of research with altmetrics? Common problems and mistakesThe impact agenda in many countries has led to increased attempts to assess the societal impacts of research. Altmetrics, webometrics, and other alternative indicators have been proposed to support this task, and many journal articles have been written that exploit alternative indicators to investigate societal impacts. Nevertheless, methodological studies of many of these indicators have revealed that extreme care must be taken with gathering, aggregating, and interpreting them. This article gives an overview of current alternative indicators, summarizes empirical research, and reports a series of common problems and mistakes to avoid when using them. The main issues are: selecting indicators to match goals; aggregating them in a way sensitive to field and publication year differences; largely avoiding them in formal evaluations; understanding that they reflect a biased fraction of the activity of interest; and understanding the type of impact reflected rather than interpreting them at face value.
Do challenge and threat evaluations predict netball performance and selection at trials in youth netball players?In the current paper, we investigated the extent to which challenge and threat evaluations predicted the trials performance of youth netball players. This paper compared two theoretical frameworks, the Theory of Challenge and Threat States in Athletes (TCTSA) and the BioPsychoSocial Model (BPSM) of Challenge and Threat, in their prediction of trials performance. A field-based cross-sectional design was adopted, including self-report psychometric, and observational performance, data. Data were collected prior to the participants’ trials performance. Youth female netball athletes (n = 92, Mage = 13.26 years, SD = 1.55) completed psychometrics concerning challenge and threat evaluations and emotions, in relation to upcoming trials performance. Performance was rated by 10 independent club coaches. Binary logistic and linear regression analyses revealed that BPSM derived resource evaluations (general self-confidence, general perception of positive challenge, positive disposition) were related to trials performance, whilst TCTSA-derived resource evaluations (self-efficacy, perceived control, goal orientation) were not. Also, a greater perceived ability to cope with demands was positively related to trial outcome. The strongest and most consistent predictor of performance was number of previous trials. The greater number of previously attended trials, the better the participants performed in trials. The findings reveal the importance of BPSM-derived resource evaluations and the perceived ability to cope with demands in the prediction of performance outcomes, over and above the TCTSA-derived resource evaluations. The findings also have important implications for sports teams, athletes, and coaches, who should strive to maximise perceptions of resources and coping abilities in the face of pressure situations, such as trials.