Dearden, J. C.Hewitt, M.Bresnen, G. M.Gregg, C. N.2017-08-312017-08-312017-07-25Dearden, J. C., Hewitt, M., Bresnen, G. M., Gregg, C. N. (2017) 'Improved correlation between animal and human potency of non-steroidal anti-inflammatory drugs using quantitative structure–activity relationships (QSARs)' SAR and QSAR in Environmental Research. 28 (7): pp. 5571062-936X10.1080/1062936X.2017.1351391http://hdl.handle.net/2436/620640Animal models are known not to predict human responses well, in general. However, we have been able to demonstrate that, for a series of non-steroidal anti-inflammatory drugs that are or were in clinical use, the incorporation of two simple physicochemical properties results in excellent correlations between human and rodent potencies for anti-inflammatory, analgesic and anti-pyretic activities. This has the potential to allow the use of historical data to improve drug development.enHuman–animal drug test correlationsQSARanalgesic activityanti-pyretic activitynon-steroidal anti-inflammatory drugsanti-inflammatory activityJournal articleSAR and QSAR in Environmental Research