Al-Taie, Zahraa SBartholomew, BarbaraColes, Simon JEvans, Daniel MHollinshead, JackieJones, LeighKraehenbuehl, RolfMurphy, Patrick JNash, Robert JPenkova, Yana BTizzard, Graham J2022-09-012022-09-012022-08-24Al-Taie, Z. S., Bartholomew, B., Coles, S. J., Evans, D. M. et al. (2022) Cyclic guanidine containing amino acids that promote glucocerebrosidase, Tetrahedron, 123, Article No. 132959. DOI: 10.1016/j.tet.2022.1329590040-402010.1016/j.tet.2022.132959http://hdl.handle.net/2436/624914This is an accepted manuscript of an article published by Elsevier in Tetrahedron on 24/08/2022, available online: https://doi.org/10.1016/j.tet.2022.132959 The accepted version of the publication may differ from the final published version.Corrigendum available at https://www.sciencedirect.com/science/article/pii/S0040402022006007Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase.application/pdfencyclic guanidinesglycosidase inhibitorsglycosidase promotersN-methylationJournal article0040-4020Tetrahedron2022-08-31132959