Cordell, HJHan, YMells, GFLi, YHirschfield, GMGreene, CSXie, GJuran, BDZhu, DQian, DCFloyd, JABMorley, KIPrati, DLleo, ACusi, DGershwin, MEAnderson, CALazaridis, KNInvernizzi, PSeldin, MFSandford, RNAmos, CISiminovitch, KASchlicht, EMLammert, CAtkinson, EJChan, LLDe Andrade, MBalschun, TMason, ALMyers, RPZhang, JMilkiewicz, PQu, JOdin, JALuketic, VABacon, BRBodenheimer, HCLiakina, VVincent, CLevy, CGregersen, PKAlmasio, PLAlvaro, DAndreone, PAndriulli, ABarlassina, CBattezzati, PMBenedetti, ABernuzzi, FBianchi, IBragazzi, MCBrunetto, MBruno, SCasella, GCoco, BColli, AColombo, MColombo, SCursaro, CCrocè, LSCrosignani, ADonato, MFElia, GFabris, LFerrari, CFloreani, AFoglieni, BFontana, RGalli, ALazzari, RMacaluso, FMalinverno, FMarra, FMarzioni, MMattalia, AMontanari, RMorini, LMorisco, FMousa Hani, SMuratori, LMuratori, PNiro, GAPalmieri, VOPicciotto, APodda, MPortincasa, PRonca, VRosina, FRossi, SSogno, ISpinzi, GSpreafico, MStrazzabosco, MTarallo, STarocchi, MTiribelli, CToniutto, PVinci, MZuin, MBrookes, Matthew2021-11-032021-11-032015-09-22Cordell, H., Han, Y., Mells, G. et al. International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways. Nature Communications, 6, 8019 (2015). https://doi.org/10.1038/ncomms901926394269 (pubmed)10.1038/ncomms9019http://hdl.handle.net/2436/624433© 2015 The Authors. Published by Springer. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/ncomms9019Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined <5 × 10-8) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist.application/pdfenLicence for published version: Creative Commons Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Canadian-US PBC ConsortiumItalian PBC Genetics Study GroupUK-PBC ConsortiumHumansLiver Cirrhosis, BiliaryGenome-Wide Association StudyJournal article2041-1723Nature Communications2020-08-07