Kitchen, PDay, RETaylor, LHJSalman, MMBill, RMConner, Matthew T.Conner, Alex C.2019-05-132019-05-132015-05-26Kitchen, P., Day, R. E., Taylor, L. H. J., Salman, M. M., Bill, R. M., Conner, M. T. and Conner, A. C. (2015) Identification and molecular mechanisms of the rapid tonicity-induced relocalization of the aquaporin 4 channel, Journal of Biological Chemistry, 290(27), pp. 16873-16881.2601382710.1074/jbc.M115.646034http://hdl.handle.net/2436/622345© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: The water channel protein aquaporin 4 (AQP4) controls water permeability of the blood-brain barrier. Results: Hypotonicity induces rapid relocalization of AQP4 in a calcium-, calmodulin-, and kinase-dependent manner. Conclusion: AQP4 can be relocalized between the cell membrane and intracellular compartments. Significance: Pharmacological modulation of AQP4 membrane localization could provide a new approach to treating brain edema.application/PDFenLicence for published version: Creative Commons Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AstrocytesCells, CulturedAnimalsHumansRatsBrain EdemaCalciumCyclic AMP-Dependent Protein KinasesCalmodulinAmino Acid MotifsProtein TransportPhosphorylationOsmotic PressureAquaporin 4HEK293 CellsJournal article1083-351XJournal of Biological Chemistry2019-05-09