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Microrna (Mirna): A new dimension in the pathogenesis of antiphospholipid syndrome (APS)
Kotyla, Przemysław J.
Kotyla, Przemysław J.
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2020-03-18
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Abstract
MicroRNAs (miRNAs) are single-stranded, endogenous RNA molecules that play a significant role in the regulation of gene expression as well as cell development, differentiation, and function. Recent data suggest that these small molecules are responsible for the regulation of immune responses. Therefore, they may act as potent modulators of the immune system and play an important role in the development of several autoimmune diseases. Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by venous and/or arterial thromboses and/or recurrent fetal losses in the presence of antiphospholipid antibodies (aPLs). Several lines of evidence suggest that like other autoimmune disorders, miRNAs are deeply involved in the pathogenesis of APS, interacting with the function of innate and adaptive immune responses. In this review, we characterize miRNAs in the light of having a functional role in the immune system and autoimmune responses focusing on APS. In addition, we also discuss miRNAs as potential biomarkers and target molecules in treating APS.
Citation
Kotyla PJ, Islam MA (2020) MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS). International Journal of Molecular Sciences. 21 (6) Article Number 2076. https://doi.org/10.3390/ijms21062076
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PubMed ID
32197340 (pubmed)
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Journal article
Language
en
Description
© 2020 The Authors. Published by MDPI AG. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website:
https://doi.org/10.3390/ijms21062076
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ISSN
1661-6596
EISSN
1422-0067
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This paper has been funded by the grant of the Medical University of Silesia, Katowice, Poland (grant number KNW-1-200/N/8/K).
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Licence for published version: Creative Commons Attribution 4.0 International