Loading...
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction
Wood, Greta K. Sargent, Brendan F. Ahmad, Zain-Ul-Abideen Tharmaratnam, Kukatharmini Dunai, Cordelia Egbe, Franklyn N. Martin, Naomi H. Facer, Bethany Pendered, Sophie L. Rogers, Henry C.
Wood, Greta K.
Sargent, Brendan F.
Ahmad, Zain-Ul-Abideen
Tharmaratnam, Kukatharmini
Dunai, Cordelia
Egbe, Franklyn N.
Martin, Naomi H.
Facer, Bethany
Pendered, Sophie L.
Rogers, Henry C.
Authors
Wood, Greta K.
Sargent, Brendan F.
Ahmad, Zain-Ul-Abideen
Tharmaratnam, Kukatharmini
Dunai, Cordelia
Egbe, Franklyn N.
Martin, Naomi H.
Facer, Bethany
Pendered, Sophie L.
Rogers, Henry C.
Hübel, Christopher
van Wamelen, Daniel J.
Bethlehem, Richard A.I.
Giunchiglia, Valentina
Hellyer, Peter J.
Trender, William
Kalsi, Gursharan
Needham, Edward
Easton, Ava
Jackson, Thomas A.
Cunningham, Colm
Upthegrove, Rachel
Pollak, Thomas A.
Hotopf, Matthew
Solomon, Tom
Pett, Sarah L.
Shaw, Pamela J.
Wood, Nicholas
Harrison, Neil A.
Miller, Karla L.
Jezzard, Peter
Williams, Guy
Duff, Eugene P.
Williams, Steven
Zelaya, Fernando
Smith, Stephen M.
Keller, Simon
Broome, Matthew
Kingston, Nathalie
Husain, Masud
Vincent, Angela
Bradley, John
Chinnery, Patrick
Menon, David K.
Aggleton, John P.
Nicholson, Timothy R.
Taylor, John-Paul
David, Anthony S.
Carson, Alan
Bullmore, Ed
Breen, Gerome
Hampshire, Adam
COVID-CNS Consortium
Sargent, Brendan F.
Ahmad, Zain-Ul-Abideen
Tharmaratnam, Kukatharmini
Dunai, Cordelia
Egbe, Franklyn N.
Martin, Naomi H.
Facer, Bethany
Pendered, Sophie L.
Rogers, Henry C.
Hübel, Christopher
van Wamelen, Daniel J.
Bethlehem, Richard A.I.
Giunchiglia, Valentina
Hellyer, Peter J.
Trender, William
Kalsi, Gursharan
Needham, Edward
Easton, Ava
Jackson, Thomas A.
Cunningham, Colm
Upthegrove, Rachel
Pollak, Thomas A.
Hotopf, Matthew
Solomon, Tom
Pett, Sarah L.
Shaw, Pamela J.
Wood, Nicholas
Harrison, Neil A.
Miller, Karla L.
Jezzard, Peter
Williams, Guy
Duff, Eugene P.
Williams, Steven
Zelaya, Fernando
Smith, Stephen M.
Keller, Simon
Broome, Matthew
Kingston, Nathalie
Husain, Masud
Vincent, Angela
Bradley, John
Chinnery, Patrick
Menon, David K.
Aggleton, John P.
Nicholson, Timothy R.
Taylor, John-Paul
David, Anthony S.
Carson, Alan
Bullmore, Ed
Breen, Gerome
Hampshire, Adam
COVID-CNS Consortium
Editors
Other contributors
Epub Date
Issue Date
2024-09-23
Submitted date
Files
Loading...
Published version
Adobe PDF, 4.47 MB
Alternative
Abstract
The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.
Citation
Wood, G.K., Sargent, B.F., Ahmad, ZUA. et al. Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction. Nature Medicine, 31, 245–257 (2025). https://doi.org/10.1038/s41591-024-03309-8
Publisher
Journal
Research Unit
PubMed ID
39312956 (pubmed)
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
© 2024 The authors. Published by Springer Nature. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/s41591-024-03309-8
Series/Report no.
ISSN
1078-8956
EISSN
1546-170X
ISBN
ISMN
Gov't Doc #
Sponsors
Members of the COVID-CNS Study Group are supported to conduct COVID-19 neuroscience research by the UK Research and Innovation/Medical Research Council (UKRI/MRC; grant no. MR/V03605X/1). G.K.W. is funded by the UK NIHR as an NIHR Academic Clinical Fellow (ACF-2022-07-007). B.D.M., G.B. and other investigators are supported by NIHR Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool, NIHR/Wellcome Trust King’s Clinical Research Facility, NIHR Maudsley Biomedical Research Centre at South London, Maudsley NHS Foundation Trust and King’s College London. B.D.M. is also supported for additional neurological inflammation research due to viral infection by grants from: the NIHR (award CO-CIN-01), the MRC (MC_PC_19059), the UKRI/MRC (MR/V007181/1), MRC (MR/T028750/1) and Wellcome (ISSF201902/3). J.-P.T. is supported by the Newcastle NIHR Biomedical Research Centre and the NIHR Dementia Translational Research Collaboration.