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The impact of level of neonatal care provision on outcomes for preterm babies born between 27 and 31 weeks of gestation, or with a birth weight between 1000 and 1500 g: a review of the literature
Ismail, Abdul Qader Tahir Boyle, Elaine M Pillay, Thillagavathie OptiPrem Study Group
Ismail, Abdul Qader Tahir
Boyle, Elaine M
Pillay, Thillagavathie
OptiPrem Study Group
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2020-03-18
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Abstract
Objective:There is evidence that birth and care in a maternity service associated with a neonatal intensive care unit (NICU) is associated with improved survival in preterm babies born at <27 weeks of gestation. We conducted a systematic review to address whether similar gains manifested in babies born between 27+0 and 31+6 weeks (hereafter 27 and 31 weeks) of gestation, or in those with a birth weight between 1000 and 1500 g. Methods:We searched Embase, Medline and CINAHL databases for studies comparing outcomes for babies born between 27 and 31 weeks or between 1000 and 1500 g birth weight, based on designation of the neonatal unit where the baby was born or subsequently cared for (NICU vs non-NICU setting). A modified QUIPS (QUality In Prognostic Studies) tool was used to assess quality. Results:Nine studies compared outcomes for babies born between 27 and 31 weeks of gestation and 11 studies compared outcomes for babies born between 1000 and 1500 g birth weight. Heterogeneity in comparator groups, birth locations, gestational age ranges, timescale for mortality reporting, and description of morbidities facilitated a narrative review as opposed to a meta-analysis. Conclusion:Due to paucity of evidence, significant heterogeneity and potential for bias, we were not able to answer our question-does place of birth or care affect outcomes for babies born between 27 and 31 weeks? This supports the need for large-scale research to investigate place of birth and care for babies born in this gestational age range.
Citation
Ismail, A.Q.T., Boyle, E.M. and Pillay, T. On behalf of The OptiPrem Study Group (2020) The impact of level of neonatal care provision on outcomes for preterm babies born between 27 and 31 weeks of gestation, or with a birth weight between 1000 and 1500 g: a review of the literature, BMJ Paediatrics Open 2020;4:e000583. doi: 10.1136/bmjpo-2019-000583
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32232179 (pubmed)
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Journal article
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en
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© 2020 The Authors. Published by BMJ. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: http://dx.doi.org/10.1136/bmjpo-2019-000583
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2399-9772
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2399-9772
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This work is supported by the NIHR HS&DR Stream, Project number 15/70/104, and by the Royal Wolverhampton NHS Trust, Protocol number 2016NEO87. AQTI is undertaking a PhD with the University of Leicester, with funding from the OptiPrem project.
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Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International