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The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
Tawari, Patricia Erebi Wang, Zhipeng Najlah, Mohammad Tsang, Chi Wai Kannappan, Vinodh Liu, Peng McConville, Christopher He, Bin Wang, Weiguang
Tawari, Patricia Erebi
Wang, Zhipeng
Najlah, Mohammad
Tsang, Chi Wai
Kannappan, Vinodh
Liu, Peng
McConville, Christopher
He, Bin
Wang, Weiguang
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2015-09-10
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Abstract
The anticancer activity of disulfiram (DS) is copper(II) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment
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The cytotoxic mechanisms of disulfiram and copper( ii ) in cancer cells 2015, 4 (6):1439 Toxicology Research
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Journal article
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en
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2045-452X
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EU Commission