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Designing of drug delivery systems to improve the antimicrobial efficacy in the periodontal pocket based on biodegradable polyesters
Zięba, Magdalena Sikorska, Wanda Musioł, Marta Janeczek, Henryk Włodarczyk, Jakub Pastusiak, Małgorzata Gupta, Abhishek Radecka, Iza Parati, Mattia Tylko, Grzegorz
Zięba, Magdalena
Sikorska, Wanda
Musioł, Marta
Janeczek, Henryk
Włodarczyk, Jakub
Pastusiak, Małgorzata
Gupta, Abhishek
Radecka, Iza
Parati, Mattia
Tylko, Grzegorz
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2023-12-29
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Abstract
Delivery systems for biologically active substances such as proanthocyanidins (PCANs), produced in the form of electrospun nonwoven through the electrospinning method, were designed using a polymeric blend of poly(L-lactide-co-glycolide) (PLGA)and poly[(R,S)-3-hydroxybutyrate] ((R,S)-PHB). The studies involved the structural and thermal characteristics of the developed electrospun three-dimensional fibre matrices unloaded and loaded with PCANs. In the next step, the hydrolytic degradation tests of these systems were performed. The release profile of PCANs from the electrospun nonwoven was determined with the aid of UV–VIS spectroscopy. Approximately 30% of the PCANs were released from the tested electrospun nonwoven during the initial 15–20 days of incubation. The chemical structure of water-soluble oligomers that were formed after the hydrolytic degradation of the developed delivery system was identified through electrospray ionization mass spectrometry. Oligomers of lactic acid and OLAGA oligocopolyester, as well as oligo-3-hydroxybutyrate terminated with hydroxyl and carboxyl end groups, were recognized as degradation products released into the water during the incubation time. It was also demonstrated that variations in the degradation rate of individual mat components influenced the degradation pattern and the number of formed oligomers. The obtained results suggest that the incorporation of proanthocyanidins into the system slowed down the hydrolytic degradation process of the poly(L-lactide-co-glycolide)/poly[(R,S)-3-hydroxybutyrate] three-dimensional fibre matrix. In addition, in vitro cytotoxicity and antimicrobial studies advocate the use of PCANs for biomedical applications with promising antimicrobial activity.
Citation
Zięba M, Sikorska W, Musioł M, Janeczek H, Włodarczyk J, Pastusiak M, Gupta A, Radecka I, Parati M, Tylko G, et al. (2024) Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters. International Journal of Molecular Sciences, 25(1):503. https://doi.org/10.3390/ijms25010503
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Journal article
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en
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© 2023 The authors. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/ijms25010503
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1661-6596
EISSN
1422-0067
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This research was funded by UM0-2016/22/Z/ST5/00692 PELARGODONT Project financed under M-ERA.NET.