Improved correlation between animal and human potency of non-steroidal anti-inflammatory drugs using quantitative structure–activity relationships (QSARs)
Dearden, J. C. Hewitt, M. Bresnen, G. M. Gregg, C. N.
Dearden, J. C.
Hewitt, M.
Bresnen, G. M.
Gregg, C. N.
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2017-07-25
Submitted date
Alternative
Abstract
Animal models are known not to predict human responses well, in general. However, we have been able to demonstrate that, for a series of non-steroidal anti-inflammatory drugs that are or were in clinical use, the incorporation of two simple physicochemical properties results in excellent correlations between human and rodent potencies for anti-inflammatory, analgesic and anti-pyretic activities. This has the potential to allow the use of historical data to improve drug development.
Citation
Dearden, J. C., Hewitt, M., Bresnen, G. M., Gregg, C. N. (2017) 'Improved correlation between animal and human potency of non-steroidal anti-inflammatory drugs using quantitative structure–activity relationships (QSARs)' SAR and QSAR in Environmental Research. 28 (7): pp. 557
Publisher
Research Unit
PubMed ID
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
Series/Report no.
ISSN
1062-936X