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Patients with gastrointestinal irritability after TGN1412-induced cytokine 2 storm displayed selective expansion of gut-homing αβ and γδ T-cells
McCarthy, Neil Stagg, Andrew Price, Claire Mann, Elizabeth Gellatly, Nichola Al-Hassi, Hafid Omar Knight, Stella Panoskaltsis, Nicki
McCarthy, Neil
Stagg, Andrew
Price, Claire
Mann, Elizabeth
Gellatly, Nichola
Al-Hassi, Hafid Omar
Knight, Stella
Panoskaltsis, Nicki
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2020-10-13
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Abstract
Following infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, three of six previously healthy, young male recipients developed gastrointestinal irritability associated with increased expression of ‘gut-homing’ integrin β7 on peripheral blood αβT-cells. This subset of patients with intestinal symptoms also displayed a striking and persistent expansion of putative Vδ2+ 7 γδT-cells in the circulation which declined over a two-year period following drug infusion, concordant with subsiding gut symptoms. These data demonstrate that TGN1412-induced gastrointestinal symptoms were associated with dysregulation of the ‘gut-homing’ pool of blood αβ and γδT11 cells, induced directly by the antibody and/or arising from the subsequent cytokine storm.
Citation
McCarthy, N.E., Stagg, A.J., Price, C.L. et al. (2021) Patients with gastrointestinal irritability after TGN1412-induced cytokine 2 storm displayed selective expansion of gut-homing αβ and γδ T-cells, Cancer Immunology Immunotherapy. 70, pp.1143–1153. https://doi.org/10.1007/s00262-020-02723-4
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Journal article
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en
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This is an accepted manuscript of an article published by Springer in Cancer Immunology, Immunotherapy on 13/10/2020, available online at: https://doi.org/10.1007/s00262-020-02723-4
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0340-7004