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Dietary phytochemicals: natural swords combating inflammation and oxidation-mediated degenerative diseases
Alam, Fahmida Solayman, Md. Khalil, Md Ibrahim Kamal, Mohammad Amjad Gan, Siew Hua
Alam, Fahmida
Solayman, Md.
Khalil, Md Ibrahim
Kamal, Mohammad Amjad
Gan, Siew Hua
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Other contributors
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Epub Date
Issue Date
2016-09-19
Submitted date
Subjects
Alternative
Abstract
Cumulatively, degenerative disease is one of the most fatal groups of diseases, and it contributes to the mortality and poor quality of life in the world while increasing the economic burden of the sufferers. Oxidative stress and inflammation are the major pathogenic causes of degenerative diseases such as rheumatoid arthritis (RA), diabetes mellitus (DM), and cardiovascular disease (CVD). Although a number of synthetic medications are used to treat these diseases, none of the current regimens are completely safe. Phytochemicals (polyphenols, carotenoids, anthocyanins, alkaloids, glycosides, saponins, and terpenes) from natural products such as dietary fruits, vegetables, and spices are potential sources of alternative medications to attenuate the oxidative stress and inflammation associated with degenerative diseases. Based on in vitro, in vivo, and clinical trials, some of these active compounds have shown good promise for development into novel agents for treating RA, DM, and CVD by targeting oxidative stress and inflammation. In this review, phytochemicals from natural products with the potential of ameliorating degenerative disease involving the bone, metabolism, and the heart are described.
Citation
Islam, M.A., Alam, F., Solayman, M., Khalil, M.I., Kamal, M.A., Gan, S.H. (2016) Dietary phytochemicals: natural swords combating inflammation and oxidation-mediated degenerative diseases. Oxidative Medicine and Cellular Longevity, 5137431. http://dx.doi.org/10.1155/2016/5137431
Publisher
Research Unit
PubMed ID
27721914 (pubmed)
PubMed Central ID
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Type
Journal article
Language
en
Description
© 2016 The Authors. Published by Wiley (Hindawi). This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1155/2016/5137431
Series/Report no.
ISSN
1942-0900
EISSN
1942-0994
ISBN
ISMN
Gov't Doc #
Sponsors
The authors would like to acknowledge the Universiti Sains Malaysia (USM) Vice-Chancellor Award (2015/2016) and the USM Global Fellowship (2014/2015) awarded to Md. Asiful Islam and Fahmida Alam, respectively, to pursue their Ph.D. degrees.
Rights
Licence for published version: Creative Commons Attribution 4.0 International