Loading...
Age-related degeneration of lumbar muscle morphology in healthy younger versus older men
Hattersley, John Diokno, Michael Tallis, Jason Renshaw, Derek Wilson, Adrian J. Wayte, Sarah C. Weedall, Andrew Duncan, Michael
Hattersley, John
Diokno, Michael
Tallis, Jason
Renshaw, Derek
Wilson, Adrian J.
Wayte, Sarah C.
Weedall, Andrew
Duncan, Michael
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2021-03-10
Submitted date
Alternative
Abstract
Aim: The aim of this study was to evaluate age-related changes in lumbar paravertebral muscle (LPM) morphology in healthy younger and older adult men. Methods: T2-weighted axial MRI of the lumbar spine were obtained for 12 healthy older (67.3 ± 6.0 years) and younger (24.7 ± 3.1 years) men. Normalised muscle volume (NMV) and muscle fat infiltrate (MFI) were determined bilaterally for the psoas (PS), quadratus lumborum (QL), erector spinae (ES) and multifidus (MF). MANOVA was used to compare NMV and MFI between age groups. Follow-up ANOVA compared NMV and MFI for each muscle between age groups, with physical activity (PA) as a covariate. Stepwise regression was used to explore the association between muscle morphology. Results: NMV of the ES and QL were significantly lower in the older group (OG) (p = 0.040 and p < 0.001, respectively). MFI across all muscles was significantly greater in the OG (p < 0.001). PA did not moderate the relationship between aging and muscle degeneration. Non-dominant handgrip strength was associated with NMV (p = 0.003). Conclusions: Age-related atrophy is muscle specific in the lumbar spine; changes in lumbar musculature is independent of PA, handgrip strength may reflect morphological changes in the postural muscles with age. This study supports establishing effective targeted exercise interventions in the lumbar musculature.
Citation
Dallaway, A., Hattersley, J., Diokno, M. et al. (2021) Age-related degeneration of lumbar muscle morphology in healthy younger versus older men. The Aging Male, 23(5), pp. 1583-1597.
Publisher
Journal
Research Unit
PubMed ID
33691587 (pubmed)
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
This is an author's accepted manuscript of an article published by Taylor & Francis in The Aging Male, available online: https://doi.org/10.1080/13685538.2021.1878130 The accepted manuscript may differ from the final published version.
Series/Report no.
ISSN
1368-5538
EISSN
1473-0790
ISBN
ISMN
Gov't Doc #
Sponsors
This publication presents independent research funded by Coventry University/University Hospitals Coventry and Warwickshire NHS Trust and carried out with the support of the National Institute of Health Research (NIHR) Coventry and Warwickshire Clinical Research Facility.