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Co-encapsulation of vitamin D and rutin in chitosan-zein microparticles
Tchuenbou-Magaia, Fideline Laure Tolve, Roberta Anyadike, Uchechukwu Giarola, Marco Favati, Fabio
Tchuenbou-Magaia, Fideline Laure
Tolve, Roberta
Anyadike, Uchechukwu
Giarola, Marco
Favati, Fabio
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2022-02-11
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Abstract
There is a growing interest in co-encapsulating multiple species to harness potential synergy between them, enhance their stability and efficacy in various products. The aim of this work was to co-encapsulate vitamin D3 and rutin inside chitosan-zein microparticles using a simple and easily scalable process for food fortification. This was achieved via anti-solvent precipitation coupled with spray-drying. Free-flowing powders of spherical microparticles with wrinkled surface and particle size < 10 μm were obtained. The encapsulation efficiency was 75% for vitamin D3 and 44% for rutin and this could be attributed to their different molecular size and affinity to the aqueous phase. The physicochemical properties were characterized by X-Ray powder diffraction and Fourier transform infrared spectroscopy. The two crystalline bioactive compounds were present in the microparticles in amorphous form, which would allow for better bioavailability when compared to non-encapsulated crystalline solid. Therefore, the obtained microparticles would be suitable for use as food ingredient for vitamin D3 fortification, with the co-encapsulated rutin acting as stability and activity enhancer.
Citation
Tchuenbou-Magaia, F.L., Tolve, R., Anyadike, U. et al. (2022) Co-encapsulation of vitamin D and rutin in chitosan-zein microparticles. Journal of Food Measurement and Characterization, 16, pp. 2060–2070. https://doi.org/10.1007/s11694-022-01340-2
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Journal article
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en
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© 2022 The Authors. Published by Springer. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1007/s11694-022-01340-2
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2193-4126
EISSN
2193-4134
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This work was supported by Regione Veneto FSE project No. 1695–16-11–2018.