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Cyclic guanidine containing amino acids that promote glucocerebrosidase
Al-Taie, Zahraa S Bartholomew, Barbara Coles, Simon J Evans, Daniel M Hollinshead, Jackie Kraehenbuehl, Rolf Murphy, Patrick J Nash, Robert J Penkova, Yana B
Al-Taie, Zahraa S
Bartholomew, Barbara
Coles, Simon J
Evans, Daniel M
Hollinshead, Jackie
Kraehenbuehl, Rolf
Murphy, Patrick J
Nash, Robert J
Penkova, Yana B
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Epub Date
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2022-08-24
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Abstract
Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase.
Citation
Al-Taie, Z. S., Bartholomew, B., Coles, S. J., Evans, D. M. et al. (2022) Cyclic guanidine containing amino acids that promote glucocerebrosidase, Tetrahedron, 123, Article No. 132959. DOI: 10.1016/j.tet.2022.132959
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Type
Journal article
Language
en
Description
This is an accepted manuscript of an article published by Elsevier in Tetrahedron on 24/08/2022, available online: https://doi.org/10.1016/j.tet.2022.132959
The accepted version of the publication may differ from the final published version.
Corrigendum available at https://www.sciencedirect.com/science/article/pii/S0040402022006007
Corrigendum available at https://www.sciencedirect.com/science/article/pii/S0040402022006007
Series/Report no.
ISSN
0040-4020
EISSN
0040-4020
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Sponsors
The authors would like to thank the Iraqi government (ZSA-T) and acknowledge the support of the Centre for Environmental Biotechnology Project part-funded by the European Regional Development Fund (ERDF) through the Welsh Government. We would like to thank the BEACON II scheme (ERDF; PJM) and the EPSRC National Mass Spectrometry Facility at Swansea.