Loading...
Vascular responses of the extremities to transdermal application of vasoactive agents in Caucasian and African descent individuals
Maley, MJ House, JR Tipton, MJ Eglin, CM
Maley, MJ
House, JR
Tipton, MJ
Eglin, CM
Authors
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2015-04-04
Submitted date
Alternative
Abstract
© 2015, Springer-Verlag Berlin Heidelberg. Purpose: Individuals of African descent (AFD) are more susceptible to non-freezing cold injury than Caucasians (CAU) which may be due, in part, to differences in the control of skin blood flow. We investigated the skin blood flow responses to transdermal application of vasoactive agents. Methods: Twenty-four young males (12 CAU and 12 AFD) undertook three tests in which iontophoresis was used to apply acetylcholine (ACh 1 w/v %), sodium nitroprusside (SNP 0.01 w/v %) and noradrenaline (NA 0.5 mM) to the skin. The skin sites tested were: volar forearm, non-glabrous finger and toe, and glabrous finger (pad) and toe (pad). Results: In response to SNP on the forearm, AFD had less vasodilatation for a given current application than CAU (P = 0.027–0.004). ACh evoked less vasodilatation in AFD for a given application current in the non-glabrous finger and toe compared with CAU (P = 0.043–0.014) with a lower maximum vasodilatation in the non-glabrous finger (median [interquartile], AFD n = 11, 41[234] %, CAU n = 12, 351[451] %, P = 0.011) and non-glabrous toe (median [interquartile], AFD n = 9, 116[318] %, CAU n = 12, 484[720] %, P = 0.018). ACh and SNP did not elicit vasodilatation in the glabrous skin sites of either group. There were no ethnic differences in response to NA. Conclusion: AFD have an attenuated endothelium-dependent vasodilatation in non-glabrous sites of the fingers and toes compared with CAU. This may contribute to lower skin temperature following cold exposure and the increased risk of cold injuries experienced by AFD.
Citation
Maley, M.J., Jouse, J.R., Tipton, M.J. and Eglin, C.M. (2015) Vascular responses of the extremities to transdermal application of vasoactive agents in Caucasian and African descent individuals, European Journal of Applied Physiology, 115, pp. 1801–1811.
Publisher
Research Unit
PubMed ID
25840674
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
This is an accepted manuscript of an article published by Springer in European Journal of Applied Physiology on 04/04/2015, available online: https://doi.org/10.1007/s00421-015-3164-2
The accepted version of the publication may differ from the final published version.
Series/Report no.
ISSN
1439-6319
EISSN
1439-6327