Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.
Panoulas, Vasileios F. Douglas, Karen M. J. Smith, Jacqueline P. Metsios, Giorgos S. Elisaf, Moses S. Nightingale, Peter Kitas, George D.
Panoulas, Vasileios F.
Douglas, Karen M. J.
Smith, Jacqueline P.
Metsios, Giorgos S.
Elisaf, Moses S.
Nightingale, Peter
Kitas, George D.
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Epub Date
Issue Date
2009
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Abstract
The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.
Citation
Clinical and Experimental Hypertension, 31(2): 93-104
Publisher
Research Unit
PubMed ID
19330599
PubMed Central ID
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Type
Journal article
Language
en
Description
Series/Report no.
ISSN
1525-6006
0148-3927
0148-3927