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Association between fish consumption and risk of dementia: a new study from China and a systematic literature review and meta-analysis.
Bakre, Aishat Chen, Ruoling Khutan, Ranjit Wei, Li Smith, Tina Qin, Gordon Danat, Isaac M Zhou, Weiju Schofield, Peter Clifford, Angela
Bakre, Aishat
Chen, Ruoling
Khutan, Ranjit
Wei, Li
Smith, Tina
Qin, Gordon
Danat, Isaac M
Zhou, Weiju
Schofield, Peter
Clifford, Angela
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Epub Date
Issue Date
2018-03-19
Submitted date
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Alternative
Abstract
To assess the association of fish consumption with risk of dementia and its dose-response relationship, and investigate variations in the association among low-, middle- and high-income countries. A new community-based cross-sectional study and a systematic literature review.SettingsUrban and rural communities in China; population-based studies systematically searched from worldwide literature. Chinese adults aged ≥60 years in six provinces (n 6981) took part in a household health survey of dementia prevalence and risk factors. In addition, 33 964 participants from eleven published and eligible studies were included in the systematic review and meta-analysis. In the new study in China, 326 participants were diagnosed with dementia (4·7 %); those who consumed any amount of fish in the past two years v. those who consumed no fish had reduced risk of dementia (adjusted OR=0·73, 95 % CI 0·64, 0·99), but the dose-response relationship was not statistically significant. The meta-analysis of available data from the literature and the new study showed relative risk (RR) of dementia of 0·80 (95 % CI 0·74, 0·87) for people with fish consumption; the impact was similar among countries with different levels of income. Pooled dose-response data revealed RR (95 % CI) of 0·84 (0·72, 0·98), 0·78 (0·68, 0·90) and 0·77 (0·61, 0·98) in people with low, middle and high consumption of fish, respectively. Corresponding figures for Alzheimer's disease were 0·88 (0·74, 1·04), 0·79 (0·65, 0·96) and 0·67 (0·58, 0·78), respectively.
Citation
Publisher
Journal
Research Unit
PubMed ID
29551101
PubMed Central ID
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Type
Journal article
Language
en
Description
Series/Report no.
ISSN
1368-9800