Loading...
Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility
Schuh, Kai Cartwright, Elizabeth J. Jankevics, Eriks Bundschu, Karin Liebermann, Jürgen Williams, Judith C. Emerson, Michael Oceandy, Delvac Knobeloch, Klaus-Peter
Schuh, Kai
Cartwright, Elizabeth J.
Jankevics, Eriks
Bundschu, Karin
Liebermann, Jürgen
Williams, Judith C.
Emerson, Michael
Oceandy, Delvac
Knobeloch, Klaus-Peter
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2004-07-31
Submitted date
Subjects
Alternative
Abstract
Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility. Furthermore, the PMCA inhibitor 5-(and-6)-carboxyeosin diacetate succinimidyl ester reduced sperm motility in wild-type animals, thus mimicking the effects of PMCA4 deficiency on sperm motility and supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca(2+) levels.
Citation
Schuh, K., Cartwright, E.J., Jankevics, E. et al. (2004) Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. Journal of Biological Chemistry, 279(27), pp. 28220-28226.
Journal
Research Unit
PubMed ID
15078889
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
Series/Report no.
ISSN
0021-9258