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Multimodal role of amino acids in microbial control and drug development
Idrees, Muhammad Mohammad, Afzal R Karodia, Nazira Rahman, Ayesha
Idrees, Muhammad
Mohammad, Afzal R
Karodia, Nazira
Rahman, Ayesha
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2020-06-17
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Abstract
Amino acids are ubiquitous vital biomolecules found in all kinds of living organisms including those in the microbial world. They are utilised as nutrients and control many biological functions in microorganisms such as cell division, cell wall formation, cell growth and metabolism, intermicrobial communication (quorum sensing), and microbial-host interactions. Amino acids in the form of enzymes also play a key role in enabling microbes to resist antimicrobial drugs. Antimicrobial resistance (AMR) and microbial biofilms are posing a great threat to the world’s human and animal population and are of prime concern to scientists and medical professionals. Although amino acids play an important role in the development of microbial resistance, they also offer a solution to the very same problem i.e., amino acids have been used to develop antimicrobial peptides as they are highly effective and less prone to microbial resistance. Other important applications of amino acids include their role as anti-biofilm agents, drug excipients, drug solubility enhancers, and drug adjuvants. This review aims to explore the emerging paradigm of amino acids as potential therapeutic moieties.
Citation
Idrees, M., Mohammad, A.R., Karodia, N. and Rahman, A. (2020) Multimodal Role of Amino Acids in Microbial Control and Drug Development. Antibiotics 2020, 9, 330.
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Journal article
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en
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© 2020 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/antibiotics9060330
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2079-6382
EISSN
2079-6382