Loading...
Association between maternal haemoglobin and stillbirth: a cohort study among a multi-ethnic population in England
Nair, Manisha Robinson, Susan Nelson-Piercy, Cathy Stanworth, Simon J Knight, Marian
Nair, Manisha
Robinson, Susan
Nelson-Piercy, Cathy
Stanworth, Simon J
Knight, Marian
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2017-10-26
Submitted date
Alternative
Abstract
The study objectives were to examine the association of maternal haemoglobin with stillbirth and perinatal death in a multi-ethnic population in England. We conducted a retrospective cohort analysis using anonymised maternity data from 14 001 women with singleton pregnancies ≥24 weeks’ gestation giving birth between 2013 and 2015 in two hospitals - the Royal Wolverhampton NHS Trust and Guy's and St Thomas’ NHS Foundation Trust. Multivariable logistic regression analyses were undertaken to analyse the associations between maternal haemoglobin at first visit and at 28 weeks with stillbirth and perinatal death, adjusting for 11 other risk factors. Results showed that 46% of the study population had anaemia (haemoglobin <110 g/l) at some point during their pregnancy. The risk of stillbirth and perinatal death decreased linearly per unit increase in haemoglobin concentration at first visit (adjusted odds ratio [aOR] stillbirth = 0·70, 95% confidence interval [CI] 0·58–0·85, aOR perinatal death = 0·71, 95% CI 0·60–0·84) and at 28 weeks (aOR stillbirth = 0·83, 95% CI 0·66–1·04; aOR perinatal death = 0·86, 95%CI 0·67–1·12). Compared with women with haemoglobin ≥110 g/l, the risk of stillbirth and perinatal death was five- and three-fold higher in women with moderate-severe anaemia (haemoglobin <100 g/l) at first visit and 28 weeks, respectively. These findings have clinical and public health importance.
Citation
Nair, M., Churchill, D., Robinson, S., Nelson‐Piercy, C. et al. (2017) Association between maternal haemoglobin and stillbirth: a cohort study among a multi‐ethnic population in England, British Journal of Haematology, 179 (5), pp. 829-837. DOI: 10.1111/bjh.14961
Publisher
Journal
Research Unit
PubMed ID
29076149 (pubmed)
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
© 2017 The Authors. Published by Wiley. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1111/bjh.14961
Series/Report no.
ISSN
0007-1048
EISSN
1365-2141
ISBN
ISMN
Gov't Doc #
Sponsors
This paper presents independent research funded by the National Institute for Health Research (NIHR) as part of a Professorship award to Marian Knight. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Rights
Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International