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Body composition of the host influences dendritic cell phenotype in patients treated for colorectal cancer
Malietzis, George Lee, Gui Han Al-Hassi, Hafid Omar Bernardo, David Blakemore, Alexandra I.F. Kennedy, Robin H. Moorghen, Morgan Jenkins, John T. Knight, Stella
Malietzis, George
Lee, Gui Han
Al-Hassi, Hafid Omar
Bernardo, David
Blakemore, Alexandra I.F.
Kennedy, Robin H.
Moorghen, Morgan
Jenkins, John T.
Knight, Stella
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2016-03-10
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Abstract
Dendritic cells (DCs) are antigen-presenting cells that can acquire tumour antigens and initiate cytotoxic T cell reactions. Obesity has been proposed as a cause for tumours escaping immune surveillance, but few studies investigate the impact of other body composition parameters. We examined the relationship of DC phenotype with computer tomography (CT)-defined parameters in patients with colorectal cancer (CRC). DCs were identified within peripheral blood mononuclear cells by flow cytometry as HLA-DR positive and negative for markers of other cell lineages in 21 patients. Analysis of CT scans was used to calculate lumbar skeletal muscle index (LSMI) and mean muscle attenuation (MA). Positive correlation between the LSMI and expression of CD40 in all DCs (r = 0.45; p = 0.04) was demonstrated. The MA was positively correlated with scavenger receptor CD36 [all DCs (r = 0.60; p = 0.01) and myeloid DCs (r = 0.63; p < 0.01)]. However, the MA was negatively correlated with CCR7 expression in all DCs (r = −0.46, p = 0.03.) and with CD83 [all DCs (r = −0.63; p = 0.01) and myeloid DCs (r = −0.75; p < 0.01)]. There were no relationships between the fat indexes and the DC phenotype. These results highlight a direct relationship between muscle depletion and changes in stimulatory, migratory and fatty acid-processing potential of DC in patients with CRC.
Citation
Malietzis, G., Lee, G.H., Al-Hassi, H.O. et al. Body composition of the host influences dendritic cell phenotype in patients treated for colorectal cancer. Tumor Biology 37, 11359–11364 (2016). https://doi.org/10.1007/s13277-016-5009-y
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PubMed ID
26960692 (pubmed)
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Journal article
Language
en
Description
This is an author's accepted manuscript of an article published by Springer in Tumor Biology on 10/03/2016, available online: https://doi.org/10.1007/s13277-016-5009-y The accepted manuscript may differ from the final published version. For re-use please see the publisher's terms and conditions.
Series/Report no.
ISSN
1423-0380
EISSN
1423-0380
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Sponsors
The authors gratefully acknowledge the support of the Biotechnology and Biological Sciences Research Council (BBSRC) (BBSRC Strategic Programme for Gut Health and Food Safety to the Institute for Food Research BB/J004529/1).