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Oligopeptide-based molecular labelling of (bio)degradable polyester biomaterials
Rydz, Joanna Duale, Khadar Sikorska, Wanda Musioł, Marta Janeczek, Henryk Marcinkowski, Andrzej Siwy, Mariola Adamus, Grażyna Mielczarek, Przemysław Silberring, Jerzy
Rydz, Joanna
Duale, Khadar
Sikorska, Wanda
Musioł, Marta
Janeczek, Henryk
Marcinkowski, Andrzej
Siwy, Mariola
Adamus, Grażyna
Mielczarek, Przemysław
Silberring, Jerzy
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2024-04-21
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Abstract
Nowadays, a very important motivation for the development of new functional materials for medical purposes is not only their performance but also whether they are environmentally friendly. In recent years, there has been a growing interest in the possibility of labelling (bio)degradable polymers, in particular those intended for specific applications, especially in the medical sector, and the potential of information storage in such polymers, making it possible, for example, to track the ultimate environmental fate of plastics. This article presents a straightforward green approach that combines both aspects using an oligopeptide, which is an integral part of polymer material, to store binary information in a physical mixture of polymer and oligopeptide. In the proposed procedure the year of production of polymer films made of poly(l-lactide) (PLLA) and a blend of poly(1,4-butylene adipate-co-1,4-butylene terephthalate) and polylactide (PBAT/PLA) were encoded as the sequence of the appropriate amino acids in the oligopeptide (PEP) added to these polymers. The decoding of the recorded information was carried out using mass spectrometry technique as a new method of decoding, which enabled the successful retrieval and reading of the stored information. Furthermore, the properties of labelled (bio)degradable polymer films and stability during biodegradation of PLLA/PEP film under industrial composting conditions have been investigated. The labelled films exhibited good oligopeptide stability, allowing the recorded information to be retrieved from a green polymer/oligopeptide system before and after biodegradation. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay) study of the PLLA and PLLA/PBAT using the MRC-5 mammalian fibroblasts was presented for the first time.
Citation
Rydz, J., Duale, K., Sikorska, W. et al. (2024) Oligopeptide-based molecular labelling of (bio)degradable polyester biomaterials. International Journal of Biological Macromolecules, 268(1), 131561.
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Journal article
Language
en
Description
This is an author's accepted manuscript of an article published by Elsevier in International Journal of Biological Macromolecules, available online: https://doi.org/10.1016/j.ijbiomac.2024.131561 The accepted manuscript may differ from the final published version.
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ISSN
0141-8130
EISSN
1879-0003
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This work was supported by the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 872152, project GREEN-MAP, an international project co-financed by the program of the Minister of Science and Higher Education entitled “PMW” in the years 2020–2024; contract No. 5092/H2020/2020/2, the statutory funds from the Maj Institute of Pharmacology at the Polish Academy of Sciences and the subsidy no 16.16.160.557 of the Polish Ministry of Science and Education, and Joint Polish-Romanian project under the agreement on scientific cooperation between the Polish Academy of Sciences and Romanian Academy of Sciences, “Design of cyclodextrin-polyester-amides for special applications”.