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Estimating regional bone mineral density-based T-scores using clinical information; tools validated for postmenopausal women in Sri Lanka
Subasinghe, Hewa Walpola Amila Sewwandi Lekamwasam, Sarath Morrissey, Hana Waidyaratne, Eisha
Subasinghe, Hewa Walpola Amila Sewwandi
Lekamwasam, Sarath
Morrissey, Hana
Waidyaratne, Eisha
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2020-09-16
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Abstract
Objectives This study aims to develop and validate a country specific osteoporosis risk assessing tool for Sri Lankan postmenopausal women. Methods Community-dwelling postmenopausal women were enrolled to development (n = 602) and validation (n = 339) samples. Clinical risk factors (CRFs) of osteoporosis were assessed. Bone mineral densities (BMD) of femoral neck, total hip and lumbar spine were assessed by dual energy X-ray absorptiometry (DXA) scan. Radial ultrasound (US) bone scan was done. Linear regression analysis was performed in development sample considering regional BMDs as dependent and CRFs as independent variables. Regression equations were developed to estimate regional BMDs using best predictive CRFs. Sensitivity, specificity, positive and negative predictive values (PPV and NPV) were assessed to validate the new tools. Results Age, body weight and US T-scores showed positive correlations with BMDs of all 3 sites. Two osteoporosis risk assessing tools (OPRATs) were developed as OPRAT-1 and OPRAT-2. Prevalence of osteoporosis, in the validation sample was 74.3%. Sensitivity were high in both tools (OPRAT-1 and OPRAT-2; 83.2% and 82.5%) while specificity were moderate (44.8% for both). PPV of OPRAT-1 and OPRAT-2 were 79.5% and 81.2%. Both tools showed moderate NPV (OPRAT-1 and OPRAT-2; 51% and 47%). Conclusions Both OPRAT-1 and OPRAT-2 have high performance in screening postmenopausal women in Sri Lanka for risk of osteoporosis. OPRAT-2 is more convenient and can be used in any healthcare setting with limited resources to identify women who will be benefitted by DXA. OPRAT-1 can be used if the radial US facility is available.
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Subasinghe, H.W.A.S., Lekamwasam, S., Ball, P., Morrissey, H. and Waidyaratne, E. (2020) Estimating regional bone mineral density-based T-scores using clinical information; tools validated for postmenopausal women in Sri Lanka, Osteoporosis and Sarcopenia, 6(3), pp. 122-128.
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© 2020 The Authors. Published by Elsevier. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1016/j.afos.2020.08.004
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2405-5255
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This study was funded by the University Grants Commission of Sri Lanka (grant number UGC/VC/DRIC/PG2016(I)/RUH/01) and the University of Wolverhampton, UK.