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Prolactinoma as a cause of persistent hyperprolactinemia in 6-Pyruvoyl-tetrahydropterin synthase deficiency
Almasseri, Zainab Nicolas- Jilwan, Manal Almadani, Ahmad Al-Owain, Mohammad Gama, Rousseau Ainuddin Sulaiman, Raashda
Almasseri, Zainab
Nicolas- Jilwan, Manal
Almadani, Ahmad
Al-Owain, Mohammad
Gama, Rousseau
Ainuddin Sulaiman, Raashda
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Epub Date
Issue Date
2020-07-14
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Abstract
6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency results in depletion of the brain neuro-transmitters serotonin and dopamine. Since dopamine is the physiological inhibitor of pituitary prolactin secretion, hyperprolactinemia is common in patients with PTPS deficiency. Serum prolactin concentrations are used for the monitoring and optimization of L-Dopa therapy. We report three adult patients with PTPS deficiency who had persistent hyperprolactinemia unresponsive to high dose L-Dopa therapy, and pituitary imaging confirmed microadenoma. In the presence of prolactinoma, serum prolactin is an unreliable tool for treatment monitoring in these patients. This report emphasizes the need to exclude other causes of hyperprolactinemia including prolactinoma, in patients who are compliant with optimized L-Dopa treatment and their prolactin levels remain significantly high.
Citation
Almasseri, Z., Nicolas- Jilwan, M., Almadani, A.K. et al. (2020) Prolactinoma as a cause of persistent hyperprolactinemia in 6-Pyruvoyl-tetrahydropterin synthase deficiency, Journal of Rare Diseases Research & Treatment, ) 5(2), pp. 1-5.
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Journal article
Language
en
Description
© 2020 The Authors. Published by Journal of Rare Diseases Research & Treatment. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://www.rarediseasesjournal.com/articles/prolactinoma-as-a-cause-of-persistent-hyperprolactinemia-in-6-pyruvoyl-tetrahydropterin-synthase-deficiency.html
Series/Report no.
ISSN
2572-9411
EISSN
2572-9411