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Seroprevalence of SARS-CoV-2 antibodies in Africa: A systematic review and meta-analysis
Hajissa, Khalid Hassan, Siti Asma Zaidah, Abdul Rahman Ismail, Nabilah Mohamed, Zeehaida
Hajissa, Khalid
Hassan, Siti Asma
Zaidah, Abdul Rahman
Ismail, Nabilah
Mohamed, Zeehaida
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Other contributors
Epub Date
Issue Date
2022-06-14
Submitted date
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Abstract
A reliable estimate of SARS-CoV-2-specific antibodies is increasingly important to track the spread of infection and define the true burden of the ongoing COVID-19 pandemic. A systematic review and a meta-analysis were conducted with the objective of estimating the seroprevalence of SARS-CoV-2 infection in Africa. A systematic search of the PubMed, Scopus, Web of Science and Google Scholar electronic databases was conducted. Thirty-five eligible studies were included. Using meta-analysis of proportions, the overall seroprevalence of anti-SARS-CoV-2 antibodies was calculated as 16% (95% CI 13.1–18.9%). Based on antibody isotypes, 14.6% (95% CI 12.2–17.1%) and 11.5% (95% CI 8.7–14.2%) were seropositive for SARS-CoV-2 IgG and IgM, respectively, while 6.6% (95% CI 4.9–8.3%) were tested positive for both IgM and IgG. Healthcare workers (16.3%) had higher seroprevalence than the general population (11.7%), blood donors (7.5%) and pregnant women (5.7%). The finding of this systematic review and meta-analysis (SRMA) may not accurately reflect the true seroprevalence status of SARS-CoV-2 infection in Africa, hence, further seroprevalence studies across Africa are required to assess and monitor the growing COVID-19 burden.
Citation
Hajissa K, Islam MA, Hassan SA, Zaidah AR, Ismail N, Mohamed Z. (2022) Seroprevalence of SARS-CoV-2 Antibodies in Africa: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 19 (12) Article Number 7257. https://doi.org/10.3390/ijerph19127257
Publisher
Research Unit
PubMed ID
35742506 (pubmed)
PubMed Central ID
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Type
Journal article
Language
en
Description
© 2022 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website:
https://doi.org/10.3390/ijerph19127257
Series/Report no.
ISSN
1661-7827
EISSN
1660-4601
ISBN
ISMN
Gov't Doc #
Sponsors
The APC was funded by the Research Creativity and Management (RCMO), Universiti Sains Malaysia (USM) and the School of Medical Sciences, USM.
Rights
Licence for published version: Creative Commons Attribution 4.0 International