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Residential greenness attenuated associations of long-term exposure to air pollution with biomarkers of advanced fibrosis
Hou, J Liu, X Zuo, T Tu, R Dong, X Li, R Pan, M Chen, Ruoling Yin, S Hu, K
Hou, J
Liu, X
Zuo, T
Tu, R
Dong, X
Li, R
Pan, M
Chen, Ruoling
Yin, S
Hu, K
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2021-08-03
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Abstract
Long-term exposure to air pollutants and residential greenness related to advanced fibrosis have been sparsely studied in low- and middle-income countries. A total of 29883 participants were selected from a cross-sectional survey of the Henan Rural Cohort. Concentrations of air pollutants (particulate matter with an aerodynamic diameter ≤ 1.0 μm (PM1), ≤ 2.5 μm (PM2.5), ≤ 10 μm (PM10) and nitrogen dioxide (NO2)) for participants were predicted by using a spatiotemporal model. Residential greenness of each participant was indicated by Enhanced Vegetation Index (EVI) and Normalized Difference Vegetation Index (NDVI). Independent and joint associations of air pollutants and residential greenness indices with prevalent advanced fibrosis reflected by fibrosis-4 score (FIB4), aspartate-to-platelet-ratio index (APRI) and ALT/AST ratio were analyzed by generalized linear mixed models and their interactive effect on prevalent advanced fibrosis were visualized by using the interplot method. Long-term exposure to PM1, PM2.5, PM10 and NO2 were positively related to FIB4 or APRI as well as prevalent intermediate-high advanced fibrosis; EVI was negatively related to FIB4 or APRI as well as prevalent intermediate-high advanced fibrosis. Negative associations of residential greenness indices (EVI or NDVI) with prevalent advanced fibrosis were decreased as increased air pollutants (PM1, PM2.5, PM10 or NO2) (P < 0.05 for all). This study indicated that residential greenness may partially attenuate negative effect of long-term exposure to air pollutants related to increased prevalent intermediate-high advanced fibrosis, implying that residential greenness may be an effective strategy to reduce the burden of prevalent hepatic fibrosis and its related disease in association with exposure high levels of air pollutants. The Henan Rural Cohort study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699, http://www.chictr.org.cn/showproj.aspx?proj=11375)
Citation
Hou, J., Liu, X., Zuo, T. et al. (2022) Residential greenness attenuated associations of long-term exposure to air pollution with biomarkers of advanced fibrosis. Environmental Science and Pollution Research 29, pp. 977–988. https://doi.org/10.1007/s11356-021-15676-7
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PubMed ID
34342826 (pubmed)
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Journal article
Language
en
Description
This is an accepted manuscript of a paper published by Springer on 03/08/2021, available online at: https://doi.org/10.1007/s11356-021-15676-7 The accepted manuscript of the publication may differ from the final published version. For re-use please see the publisher's terms and conditions.
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ISSN
0944-1344
EISSN
1614-7499
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Sponsors
This research was supported by the Foundation of National Key Program of Research and Development of China (Grant No: 2016YFC0900803), Science and Technology Innovation Team Support Plan of Colleges and Universities in Henan Province (Grant No: 21IRTSTHN029), China Postdoctoral Science Foundation (Grant No: 2019M662548), National Natural Science Foundation of China (Grant No: 81930092), Foundation of Medical Science and Technology of Henan Province (No: 201702367, 2017T02098), and Discipline Key Research and Development Program of Zhengzhou University (Grant No: XKZDQY202008, XKZDQY202002).