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Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations
Molina, Carlos Kaialy, Waseem Chen, Qiao Commandeur, Daniel Nokhodchi, Ali
Molina, Carlos
Kaialy, Waseem
Chen, Qiao
Commandeur, Daniel
Nokhodchi, Ali
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2017-12-19
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Abstract
Spray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1, 5, and 10% w/v) were incorporated into lactose monohydrate solution for spray-drying to enhance the aerosolization performance of dry powder inhalers containing spray-dried lactoseleucine and salbutamol sulfate. The prepared spray-dried lactose-leucine carriers were analyzed using laser diffraction (particle size), differential scanning calorimetry (thermal behavior), scanning electron microscopy (morphology), powder X-ray diffraction (crystallinity), Fourier transform infrared spectroscopy (interaction at molecular level), and in vitro aerosolization performance (deposition). The results showed that the efficacy of salbutamol sulfateās aerosolization performance was, in part, due to the introduction of L-leucine in the carrier, prior to being spray-dried, accounting for an increase in the fine particle fraction (FPF) of salbutamol sulfate from spray-dried lactose-leucine (0.5% leucine) in comparison to all other carriers. It was shown that all of the spray-dried carriers were spherical in their morphology with some agglomerates and contained a mixture of amorphous, Ī±- lactose, and Ī²-lactose. It was also interesting to note that spray-dried lactose-leucine particles were agglomerated during the spray-drying process to make coarse particles (volume mean diameter of 79 to 87 Ī¼m) suitable as a carrier in DPI formulations.
Citation
Molina C., Kaialy W., Chen Q., Commandeur D., Nokhodchi A. (2017) 'Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations', Drug Delivery and Translational Research, 8 (6) pp. 1769-1780. doi: 10.1007/s13346-017-0462-8
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Journal article
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en
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This is an accepted manuscript of an article published by Springer in Drug delivery and translational research on 19/12/2017, available online: https://doi.org/10.1007/s13346-017-0462-8
The accepted version of the publication may differ from the final published version.
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2190-393X