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Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: A pilot study
Liu, Xiaoxuan Kale, Aditya Udya Capewell, Nicholas Talbot, Nicholas Ahmed, Sumiya Keane, Pearse A Mollan, Susan Belli, Antonio Blanch, Richard J
Liu, Xiaoxuan
Kale, Aditya Udya
Capewell, Nicholas
Talbot, Nicholas
Ahmed, Sumiya
Keane, Pearse A
Mollan, Susan
Belli, Antonio
Blanch, Richard J
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2019-11-07
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Abstract
Objective This study aims to evaluate the feasibility of retinal imaging in critical care using a novel mobile optical coherence tomography (OCT) device. The Heidelberg SPECTRALIS FLEX module (Heidelberg Engineering, Heidelberg, Germany) is an OCT unit with a boom arm, enabling ocular OCT assessment in less mobile patients. Design We undertook an evaluation of the feasibility of using the SPECTRALIS FLEX for undertaking ocular OCT images in unconscious and critically ill patients. Setting This study was conducted in the critical care unit of a large tertiary referral unit in the United Kingdom. Participants 13 systemically unwell patients admitted to the critical care unit were purposively sampled to enable evaluation in patients with a range of clinical states. Outcome measures The primary outcome was the feasibility of acquiring clinically interpretable OCT scans on a consecutive series of patients. The standardised scanning protocol included macula-focused OCT, OCT optic nerve head (ONH), OCT angiography (OCTA) of the macula and ONH OCTA. Results OCT images from 13 patients were attempted. The success rates of each scan type are 84% for OCT macula, 76% for OCT ONH, 56% for OCTA macula and 36% for OCTA ONH. The overall mean success rate of scans per patient was 64% (95% CI 46% to 81%). Clinicians reported clinical value in 100% scans which were successfully obtained, including both ruling in and ruling out relevant ocular complications such as corneal thinning, macular oedema and optic disc swelling. The most common causes of failure to achieve clinically interpretable scans were inadequately sustained OCT alignment in delirious patients and a compromised ocular surface due to corneal exposure. Conclusions This prospective evaluation indicates the feasibility and potential clinical value of the SPECTRALIS FLEX OCT system on the critical care unit. Portable OCT systems have the potential to bring instrument-based ophthalmic assessment to critically ill patients, enabling detection and micron-level monitoring of ocular complications.
Citation
Liu X, Kale AU, Capewell N, et alOptical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot studyBMJ Open 2019;9:e030882. doi: 10.1136/bmjopen-2019-030882
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Research Unit
PubMed ID
31699727 (pubmed)
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Journal article
Language
en
Description
https://doi.org/10.1136/bmjopen-2019-030882
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ISSN
2044-6055
EISSN
2044-6055
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Sponsors
XL, PAK and AKD receive a proportion of their funding from the Wellcome Trust, through a Health Improvement Challenge grant (200141/Z/15/Z). AKD and PAK receive a proportion of their funding from the Department of Health’s NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology. TV, NT and AB receive a proportion of their funding from Queen Elizabeth Hospital Birmingham Charities.
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Licence for published version: Creative Commons Attribution 4.0 International