Loading...
The rs9340799 polymorphism of the estrogen receptor alpha (ESR1) gene and its association with breast cancer susceptibility
Tan, Shing Cheng Low, Teck Yew Mohamad Hanif, Ezanee Azlina Sharzehan, Mohamad Ayub Khan Kord-Varkaneh, Hamed
Tan, Shing Cheng
Low, Teck Yew
Mohamad Hanif, Ezanee Azlina
Sharzehan, Mohamad Ayub Khan
Kord-Varkaneh, Hamed
Editors
Other contributors
Epub Date
Issue Date
2021-09-20
Submitted date
Subjects
Alternative
Abstract
The ESR1 rs9340799 polymorphism has been frequently investigated with regard to its association with breast cancer (BC) susceptibility, but the findings have been inconclusive. In this work, we aimed to address the inconsistencies in study findings by performing a systematic review and meta-analysis. Eligible studies were identified from the Web of Science, PubMed, Scopus, China National Knowledge Infrastructure, VIP and Wanfang databases based on the predefined inclusion and exclusion criteria. The pooled odds ratio (OR) was then calculated under five genetic models: homozygous (GG vs. AA), heterozygous (AG vs. AA), dominant (AG + GG vs. AA), recessive (GG vs. AA + AG) and allele (G vs. A). Combined results from 23 studies involving 34,721 subjects indicated a lack of significant association between the polymorphism and BC susceptibility (homozygous model, OR = 1.045, 95% CI 0.887–1.231, P = 0.601; heterozygous model, OR = 0.941, 95% CI 0.861–1.030, P = 0.186; dominant model, OR = 0.957, 95% CI 0.875–1.045, P = 0.327; recessive model, OR = 1.053, 95% CI 0.908–1.222, P = 0.495; allele model, OR = 0.987, 95% CI 0.919–1.059, P = 0.709). Subgroup analyses by ethnicity, menopausal status and study quality also revealed no statistically significant association (P > 0.05). In conclusion, our results showed that the ESR1 rs9340799 polymorphism was not associated with BC susceptibility, suggesting its limited potential as a genetic marker for BC.
Citation
Tan, S.C., Low, T.Y., Mohamad Hanif, E.A. et al. The rs9340799 polymorphism of the estrogen receptor alpha (ESR1) gene and its association with breast cancer susceptibility. Sci Rep 11, 18619 (2021). https://doi.org/10.1038/s41598-021-97935-8
Publisher
Journal
Research Unit
PubMed ID
34545128 (pubmed)
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
© 2021 The Authors. Published by Nature Publishing Group. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website:
https://doi.org/10.1038/s41598-021-97935-8
Series/Report no.
ISSN
2045-2322
EISSN
2045-2322
ISBN
ISMN
Gov't Doc #
Sponsors
Research in SCT’s laboratory is supported by the Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia (No. FRGS/1/2019/SKK08/UKM/02/9) and the Research University Grant of Universiti Kebangsaan Malaysia (No. GUP-2020-076).
Rights
Licence for published version: Creative Commons Attribution 4.0 International