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Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis
Fenton, Sally A. M. Sandoo, Aamer Metsios, George S. Duda, Joan L. Kitas, George D. Veldhuijzen van Zanten, Jet J.C.S.
Fenton, Sally A. M.
Sandoo, Aamer
Metsios, George S.
Duda, Joan L.
Kitas, George D.
Veldhuijzen van Zanten, Jet J.C.S.
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2018-02-21
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Abstract
Background: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. Objectives: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. Methods: Sixty-eight RA patients (Mage = 55±12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire). Results: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = − 3.25, p = .02, 95% CI [– 6.07, – .42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN). Conclusion: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.
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Fenton, S.A., Sandoo, A., Metsios, G.S., Duda, J.L., Kitas, G.D., & Zanten, J.J. (2018). Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis. Microvascular research, 117 (may 2018), pp 57-60.
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Journal article
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en
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0026-2862