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Non-alcoholic fatty liver disease (NAFLD) and potential links to depression, anxiety, and chronic stress
Shea, Sue Lionis, Christos Atkinson, Lou Chaggar, Surinderjeet S. Randeva, Harpal S. Kyrou, Ioannis
Shea, Sue
Lionis, Christos
Atkinson, Lou
Chaggar, Surinderjeet S.
Randeva, Harpal S.
Kyrou, Ioannis
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2021-11-16
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Abstract
Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease worldwide, and is frequently linked to the metabolic syndrome. The latter represents a clustering of related cardio-metabolic components, which are often observed in patients with NAFLD and increase the risk of cardiovascular disease. Furthermore, growing evidence suggests a positive association between metabolic syndrome and certain mental health problems (e.g., depression, anxiety, and chronic stress). Given the strong overlap between metabolic syndrome and NAFLD, and the common underlying mechanisms that link the two conditions, it is probable that potentially bidirectional associations are also present between NAFLD and mental health comorbidity. The identification of such links is worthy of further investigation, as this can inform more targeted interventions for patients with NAFLD. Therefore, the present review discusses published evidence in relation to associations of depression, anxiety, stress, and impaired health-related quality of life with NAFLD and metabolic syndrome. Attention is also drawn to the complex nature of affective disorders and potential overlapping symptoms between such conditions and NAFLD, while a focus is also placed on the postulated mechanisms mediating associations between mental health and both NAFLD and metabolic syndrome. Relevant gaps/weaknesses of the available literature are also highlighted, together with future research directions that need to be further explored.
Citation
Shea S, Lionis C, Kite C, Atkinson L, Chaggar SS, Randeva HS, Kyrou I. (2021) Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress. Biomedicines, 9(11):1697. https://doi.org/10.3390/biomedicines9111697
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34829926 (pubmed)
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Journal article
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en
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© 2021 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/biomedicines9111697
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2227-9059
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2227-9059
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Licence for published version: Creative Commons Attribution 4.0 International