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Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China
Chen, Ruoling Song, Lulu Liu, Bingqing Wang, Lulin Wu, Mingyang Zhang, Lina Liu, Yunyun Bi, Jianing Yang, Senbei Zhang, Bin
Chen, Ruoling
Song, Lulu
Liu, Bingqing
Wang, Lulin
Wu, Mingyang
Zhang, Lina
Liu, Yunyun
Bi, Jianing
Yang, Senbei
Zhang, Bin
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2019-11-11
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Abstract
Background: Arsenic (As) is a widely distributed environmental chemical with potentially different toxicities. However, little is known about the impact of maternal As exposure on newborn mitochondrial DNA copy number (mtDNAcn), which may lie on the pathway linking As exposure to adverse health impacts. Objectives: We aimed to explore whether maternal As exposure was associated with newborn mtDNAcn. Methods: We conducted a birth cohort study of 762 mother-infant pairs in Wuhan, China, 2013-2015. Cord blood mtDNAcn was determined using qPCR. Maternal urinary As levels in each trimester were quantified by ICP-MS. Multiple informant models were used to examine the associations of repeated urinary As levels with cord blood mtDNAcn. Results: The median urinary As levels in the first, second, and third trimesters were 17.2 g/L, 16.0 g/L and 17.0 g/L respectively. In the multivariate model, each doubling increase in the first-trimester urinary As level was associated with a 6.6% (95% CI: -12.4%, -0.5%) decrease in cord blood mtDNAcn. The highest versus lowest quintile of first-trimester urinary As level was related to a 19.0% (95% CI: -32.9%, -2.2%) lower cord blood mtDNAcn. There was significant association of urinary As levels in the second and third trimesters with cord blood mtDNAcn. The inverse relationship between first-trimester urinary As level and cord blood mtDNAcn was more pronounced among female infants. Conclusions: First-trimester As exposure was associated with decreased cord blood mtDNAcn. The potential health impacts of decreased mtDNAcn in early life need to be further clarified.
Citation
Song, L., Liu, B., Wang, L., Wu, M., Zhang, L., Liu, Y., Bi, J., Yang, S., Zhang, B., Xia, W., Xu, S., Chen, R., Cao, Z. and Wang, Y. (2020) Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China, Chemosphere, 243(March 2020), 125335.
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Journal article
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en
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This is an accepted manuscript of an article published by Elsevier in Chemosphere on 11/11/2019, available online: https://www.sciencedirect.com/science/article/abs/pii/S0045653519325755?via%3Dihub
The accepted version of the publication may differ from the final published version.
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0045-6535