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The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain.

Pangeni, Rajendra P
; 
Channathodiyil, Prasanna
; 
Huen, David S
; 
Eagles, Lawrence W
; 
Johal, Balraj K
; 
Pasha, Dawar
; 
Hadjistephanou, Natasa
; 
Nevell, Oliver
; 
Davies, Claire L
; 
Adewumi, Ayobami I
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Authors
Pangeni, Rajendra P
 Channathodiyil, Prasanna
 Huen, David S
 Eagles, Lawrence W
 Johal, Balraj K
 Pasha, Dawar
 Hadjistephanou, Natasa
 Nevell, Oliver
 Davies, Claire L
 Adewumi, Ayobami I
 Khanom, Hamida
 Samra, Ikroop S
 Buzatto, Vanessa C
 Chandrasekaran, Preethi
 Shinawi, Thoraia
 Dawson, Timothy P
 Ashton, Katherine
 Davis, Charles
 Brodbelt, Andrew R
 Jenkinson, Michael D
 Bièche, Ivan
 Latif, Farida
 Darling, John L
 Warr, Tracy J
 Morris, Mark R.
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Issue Date
2015-05-27
Submitted date
Subjects
Brain
 Breast
 DNA methylation
 Epigenetic
 Metastasis
 Tumour suppressor
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Abstract
Tumour metastasis to the brain is a common and deadly development in certain cancers; 18-30 % of breast tumours metastasise to the brain. The contribution that gene silencing through epigenetic mechanisms plays in these metastatic tumours is not well understood.
Citation
Pangeni, R.P., Channathodiyil, P., Huen, D.S. et al. The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain. Clin Epigenet 7, 57 (2015). https://doi.org/10.1186/s13148-015-0089-x
Publisher
BioMed Central
Journal
Clinical epigenetics
Research Unit
URI
http://hdl.handle.net/2436/621319
DOI
10.1186/s13148-015-0089-x
PubMed ID
26052355
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Journal article
Language
en
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1868-7075
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