Loading...
Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children
Deli, Chariklia K Fatouros, Ioannis G Paschalis, Vassilis Tsiokanos, Athanasios Georgakouli, Kalliopi Zalavras, Athanasios Avloniti, Alexandra Koutedakis, Yiannis Jamurtas, Athanasios Z
Deli, Chariklia K
Fatouros, Ioannis G
Paschalis, Vassilis
Tsiokanos, Athanasios
Georgakouli, Kalliopi
Zalavras, Athanasios
Avloniti, Alexandra
Koutedakis, Yiannis
Jamurtas, Athanasios Z
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2017
Submitted date
Subjects
Alternative
Abstract
Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n = 14) and children (n = 11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status. Iron supplementation at rest increased iron concentration and transferrin saturation (p < 0.01). In adults, CK activity increased at 72 h after exercise, while no changes occurred in children. Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition. Eccentric exercise decreased bilirubin concentration at 72 h in all groups. Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children. This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis. This study was registered at Clinicaltrials.gov Identifier: NCT02374619.
Citation
Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. 2017, 2017:4120421 Oxid Med Cell Longev
Publisher
Research Unit
PubMed ID
28203319
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
Series/Report no.
ISSN
1942-0900