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Thymoquinone : hydroxypropyl-β-cyclodextrin loaded bacterial cellulose for the management of wounds
Swingler, Sam Gupta, Abhishek Gibson, Hazel Kowalczuk, Marek Adamus, Grazyna
Swingler, Sam
Gupta, Abhishek
Gibson, Hazel
Kowalczuk, Marek
Adamus, Grazyna
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2022-12-15
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Abstract
The need for more advantageous and pharmaceutically active wound dressings is a pressing matter in the area of wound management. In this study, we explore the possibility of incorporating thymoquinone within bacterial cellulose, utilising cyclodextrins as a novel method of solubilising hydrophobic compounds. The thymoquinone was not soluble in water, so was incorporated within hydroxypropyl-β-cyclodextrin before use. Thymoquinone: hydroxypropyl-β-cyclodextrin inclusion complex produced was found to be soluble in water up to 7% (w/v) and was stable with no crystal formation for at least 7 days with the ability to be loaded within the bacterial cellulose matrix. The inclusion complex was found to be thermally stable up to 280 °C which is far greater than the production temperature of 80 °C and was stable in phosphate-buffered saline and extraction solvents in permeation and dose experiments. The adhesion properties of the Thymoquinone: hydroxypropyl-β-cyclodextrin loaded bacterial cellulose dressings were tested and found to be 2.09 N. Permeation studies on skin mimicking membrane Strat-M showed a total permeated amount (0–24 h) of 538.8 µg cm−2 and average flux after a 2 h lag of 22.4 µg h−1 cm−2. To the best of our knowledge, the methods outlined in this study are the first instance of loading bacterial cellulose with thymoquinone inclusion complex with the aim of producing a pharmaceutically active wound dressing.
Citation
Swingler S, Gupta A, Gibson H, Kowalczuk M, Adamus G, Heaselgrave W, Radecka I. (2022) Thymoquinone: Hydroxypropyl-β-cyclodextrin Loaded Bacterial Cellulose for the Management of Wounds. Pharmaceutics, 14(12):2816. https://doi.org/10.3390/pharmaceutics14122816
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Journal article
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en
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© 2022 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/pharmaceutics14122816
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1999-4923
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1999-4923
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This research was partially funded by the University of Wolverhampton Research Investment Fund (RIF4).